4-Fluoro-N-isopropylaniline
A high-purity fluorinated secondary aromatic amine supplied for pharmaceutical and agrochemical intermediate synthesis and custom fine chemical manufacture.
What is 4-Fluoro-N-isopropylaniline?
4-Fluoro-N-isopropylaniline — FIA — is a pale yellow to amber liquid combining a para-fluorinated ring with a secondary amine carrying an isopropyl group on the nitrogen. It is normally made by reductive amination of 4-fluoroaniline with acetone.
Both features earn their place. The fluorine blocks metabolic oxidation at that ring position and raises lipophilicity, while N-alkylation removes one N–H and adds steric bulk, changing how the nitrogen behaves in acylation and cyclisation compared with a plain primary aniline.
At Chelora Chemicals, FIA is distilled to high assay and low colour, with residual 4-fluoroaniline and moisture controlled, since unreacted primary amine is the impurity most likely to cause trouble in downstream acylation.
- Appearance
- Pale yellow to amber liquid
- Odour
- Characteristic amine odour
- Solubility
- Slightly soluble in water; soluble in organic solvents
- Function
- Chemical intermediate
- Grade
- High purity / pharma intermediate
Formula diagram
Para-fluorinated ring with an N-isopropyl secondary amine
- Molecular formulaC9H12FN
- Molecular weight153.20 g/mol
- IUPAC name4-Fluoro-N-(propan-2-yl)aniline
- Functional groupsSecondary aromatic amine, aryl fluoride
- CAS number70441-63-3
Technical product information
Standard specification for Chelora Chemicals' high-purity intermediate 4-Fluoro-N-isopropylaniline. Custom-grade and bulk specifications are available on request.
| Chemical name | 4-Fluoro-N-isopropylaniline |
|---|---|
| Synonyms | FIA, N-Isopropyl-4-fluoroaniline, N-(4-Fluorophenyl)isopropylamine |
| CAS number | 70441-63-3 |
| Molecular formula | C9H12FN |
| Molecular weight | 153.20 g/mol |
| Assay (GC purity) | ≥ 98.0% |
| Appearance | Pale yellow to amber liquid |
| Density (20°C) | 1.03–1.06 g/cm³ |
| Residual 4-fluoroaniline | ≤ 0.5% |
| Water content | ≤ 0.3% |
| Packaging | 25 kg & 200 kg drums |
| Storage | Cool, dark, under inert atmosphere |
| Shelf life | 12 months in sealed original packaging |
Applications of 4-Fluoro-N-isopropylaniline
Pharmaceutical intermediates
Supplies a fluorinated N-alkyl aniline fragment for API and development compound synthesis.
Agrochemical intermediates
Acylated or carbamoylated in the synthesis of crop-protection actives and their reference standards.
Carbamate & amide chemistry
The secondary amine reacts cleanly with isocyanates, acid chlorides, and chloroformates.
Heterocyclic synthesis
Used to build fluorinated nitrogen heterocycles where an N-substituted aniline is required.
Analytical reference material
Supplied as a reference standard for impurity profiling in related agrochemical actives.
Custom synthesis
Available as a building block for research and contract manufacturing programmes.
Why choose Chelora Chemicals
Every batch of 4-Fluoro-N-isopropylaniline is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
GC assay controlled at ≥98% with residual primary amine, colour, and water content verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 25 kg drums to 200 kg drums, with laboratory samples on request.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly sealed original containers under nitrogen — this product oxidises readily in air.
- 02Keep cool and dark; refrigerated storage materially extends colour and assay stability.
- 03Protect from light; secondary aromatic amines darken faster than most primary anilines.
- 04Segregate from strong oxidising agents, acids, acid chlorides, and isocyanates.
- 05Use compatible containers: glass, stainless steel, or lined steel.
- 06Re-seal and re-blanket containers immediately after each withdrawal.
Handling precautions
FIA is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation. It is for industrial use by trained personnel only.
Aromatic amines are absorbed through intact skin and can affect the blood by forming methaemoglobin. Chemical-resistant gloves, coveralls, and eye protection are required.
Use local exhaust ventilation for drum decanting, charging, and heated operations, and avoid breathing vapour or mist.
Reaction with acid chlorides, isocyanates, and chloroformates is exothermic and requires controlled addition and cooling at scale.
Refer to the full Safety Data Sheet for exposure limits, spill containment, disposal, and first-aid measures before use.
Frequently asked questions
What is 4-Fluoro-N-isopropylaniline used for?
It is a building block for pharmaceutical and agrochemical intermediates, particularly where the secondary amine is acylated or carbamoylated. It is also supplied as an analytical reference material for impurity work.
How is FIA manufactured?
Most commonly by reductive amination: 4-fluoroaniline is condensed with acetone and the resulting imine is reduced. Residual 4-fluoroaniline from incomplete conversion is the impurity most worth watching.
Why does residual 4-fluoroaniline matter?
The primary amine is more nucleophilic than the secondary one, so it reacts first and faster in acylation. Even a small amount produces a distinct by-product that then has to be separated, which is why it is specified rather than left as an unquantified impurity.
How does a secondary amine differ from a primary aniline in practice?
It has only one N–H, so it forms tertiary amides rather than secondary ones, cannot be diazotised, and is more sterically hindered. That changes both the products it forms and the conditions needed to form them.
Why does the product darken during storage?
Secondary aromatic amines oxidise readily on contact with air and light. Darkening is normal and does not necessarily mean the assay has dropped, but nitrogen blanketing and cool, dark storage slow it considerably.
What storage conditions do you recommend?
Sealed containers under nitrogen, kept cool and out of light. Refrigerated storage is worthwhile for material that will be held for several months or used in colour-sensitive work.
Is it soluble in water?
Only slightly. It dissolves readily in alcohols, ethers, esters, and aromatic hydrocarbons, so reactions are run in organic media.
What purity do you supply?
Standard grade is supplied at a minimum GC assay of 98% with residual 4-fluoroaniline at or below 0.5% and water at or below 0.3%. Higher assay and tighter colour specifications can be manufactured to order.
What packaging sizes are available?
25 kg and 200 kg drums under nitrogen, with laboratory and pilot samples available for development work.
Is FIA hazardous?
Yes. It is harmful by several routes, skin-absorbable, irritating to skin and eyes, and hazardous to aquatic life. Engineering controls, PPE, and the Safety Data Sheet should be reviewed before handling.
Do you provide a Certificate of Analysis?
Yes. Every batch is dispatched with a Certificate of Analysis and Safety Data Sheet covering GC assay, residual primary amine, density, water content, colour, and appearance.