2,6-Dichlorofluorobenzene
A high-purity mixed-halogen aromatic supplied for pharmaceutical, agrochemical, dye, and liquid crystal intermediate synthesis.
What is 2,6-Dichlorofluorobenzene?
2,6-Dichlorofluorobenzene — systematically 1,3-dichloro-2-fluorobenzene — is a low-melting solid that is often handled as a liquid, carrying a fluorine flanked by chlorine atoms on both neighbouring carbons.
That arrangement gives synthetic chemists two different halogen handles on one ring. The chlorines participate in metal-catalysed coupling and substitution chemistry, while the fluorine generally stays in place and becomes a permanent feature of the finished molecule.
At Chelora Chemicals, 26DCFB is distilled to high assay with isomer content and moisture controlled, since impurities introduced here carry through every subsequent step of a pharmaceutical or agrochemical route.
- Appearance
- Colourless to pale yellow liquid or low-melting solid
- Odour
- Characteristic aromatic
- Solubility
- Insoluble in water; soluble in most organic solvents
- Function
- Chemical intermediate
- Grade
- High purity
Formula diagram
Fluorine flanked by chlorine on both adjacent ring positions
- Molecular formulaC6H3Cl2F
- Molecular weight164.99 g/mol
- IUPAC name1,3-Dichloro-2-fluorobenzene
- Functional groupsAryl chloride, aryl fluoride
- CAS number2268-05-5
Technical product information
Standard specification for Chelora Chemicals' high-purity intermediate 2,6-Dichlorofluorobenzene. Custom-grade and bulk specifications are available on request.
| Chemical name | 2,6-Dichlorofluorobenzene |
|---|---|
| Synonyms | 26DCFB, 1,3-Dichloro-2-fluorobenzene, 2-Fluoro-1,3-dichlorobenzene |
| CAS number | 2268-05-5 |
| Molecular formula | C6H3Cl2F |
| Molecular weight | 164.99 g/mol |
| Assay (GC purity) | ≥ 99.0% |
| Appearance | Colourless to pale yellow liquid or low-melting solid |
| Melting point | 35–38°C |
| Boiling point | 168–169°C |
| Density (40°C) | 1.40–1.45 g/cm³ |
| Flash point | 60°C (closed cup) |
| Water content | ≤ 0.1% |
| Packaging | 25 kg & 200 kg drums |
| Shelf life | 24 months in sealed original packaging |
Applications of 2,6-Dichlorofluorobenzene
Pharmaceutical intermediates
Used to build halogenated aromatic cores in API and development compound synthesis.
Agrochemical intermediates
Introduces a mixed-halogen aromatic fragment into crop-protection actives.
Liquid crystal materials
Feeds fluorinated intermediates used in display-grade material manufacture.
Dye intermediates
Applied in halogenated colour intermediates requiring both chlorine and fluorine.
Cross-coupling chemistry
The chlorines serve as handles for palladium-catalysed coupling and metalation routes.
Custom synthesis
Supplied as a research and contract manufacturing building block.
Why choose Chelora Chemicals
Every batch of 2,6-Dichlorofluorobenzene is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
GC assay controlled at ≥99% with isomer profile and low moisture verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 25 kg drums to 200 kg drums, with laboratory samples for development work.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly sealed original containers in a cool, dry, well-ventilated store.
- 02Keep away from heat, sparks, and open flame — the flash point is 60°C.
- 03Expect the product to solidify below about 35°C; warm gently and evenly before transfer.
- 04Protect from moisture, which matters for downstream metalation and coupling chemistry.
- 05Use compatible containers: glass, stainless steel, or lined steel, blanketed with nitrogen where practical.
- 06Earth and bond containers and lines during transfer, and bund all bulk storage.
Handling precautions
The product is a combustible liquid with a flash point of 60°C. Eliminate ignition sources and control static during transfer.
It is harmful if swallowed or inhaled and causes skin, eye, and respiratory irritation. Chemical-resistant gloves, eye protection, and adequate ventilation are required.
Warming solidified material should be done with controlled, even heating — never with direct flame or a localised high-temperature source.
Avoid release to the environment and contain all spills with inert absorbent for licensed disposal.
Refer to the full Safety Data Sheet for exposure limits, fire-fighting measures, spill response, and first-aid information before use.
Frequently asked questions
What is 2,6-Dichlorofluorobenzene used for?
It is an intermediate for pharmaceutical, agrochemical, dye, and liquid crystal materials, valued for giving two chemically distinct halogen handles on the same aromatic ring.
What is its correct systematic name?
1,3-Dichloro-2-fluorobenzene. The common trade name 2,6-dichlorofluorobenzene numbers the ring from the fluorine instead, which is why both names appear in catalogues for the same CAS number, 2268-05-5.
How many chlorines and fluorines does it contain?
Two chlorines and one fluorine, formula C6H3Cl2F, molecular weight 164.99. It is worth confirming this on any enquiry, because the similar-sounding chlorodifluorobenzenes have one chlorine and two fluorines and a different molecular weight.
Why do the chlorines react while the fluorine does not?
Carbon–chlorine bonds are weaker and more polarisable, so they undergo oxidative addition and metalation far more readily. Without strong activating groups on the ring, the carbon–fluorine bond is essentially inert and survives into the final molecule.
Is it a liquid or a solid?
It depends on the temperature. The melting point is around 35–38°C, so it is a solid in a cool store and a liquid in a warm one. Drums often arrive partly solidified and need gentle warming before transfer.
Is it soluble in water?
No. It is practically insoluble in water and readily soluble in THF, ether, toluene, and most solvents used for coupling chemistry.
What purity do you supply?
Standard grade is supplied at a minimum GC assay of 99% with water content at or below 0.1%. Tighter isomer, metals, and colour specifications can be manufactured for pharmaceutical intermediate use.
What packaging sizes are available?
25 kg and 200 kg drums, with laboratory and pilot samples available for development and qualification work.
Why is the flash point significant?
At 60°C it is classified as a combustible liquid, and any warming step to liquefy solidified material moves it closer to that temperature. Ignition source control and bonding during transfer are essential.
How should it be stored?
In sealed original containers in a cool, dry, ventilated store away from ignition sources and moisture. Nitrogen blanketing is recommended for opened containers.
Do you provide a Certificate of Analysis?
Yes. Every batch is dispatched with a Certificate of Analysis and Safety Data Sheet covering GC assay, melting range, density, water content, and appearance.