1,3-Diisopropyl-2-isothiocyanato-5-phenoxybenzene DIPPI · CAS 80058-93-1
Chelora Chemicals is a supplier of DIPPI, the hindered aryl isothiocyanate that serves as the key late-stage intermediate in diafenthiuron manufacture. The isothiocyanate group is the reactive point; the two isopropyl groups and the phenoxy ether are carried straight through into the finished active. Every consignment leaves with a batch-specific COA and the current SDS.
Also known as: DIPPI, 2,6-Diisopropyl-4-phenoxyphenyl isothiocyanate, 4-Phenoxy-2,6-diisopropylphenyl isothiocyanate, 2-Isothiocyanato-1,3-bis(1-methylethyl)-5-phenoxybenzene
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Price, lead time and a sample COA for DIPPI, usually within one working day. We ship worldwide.
Request a Quote Email the DeskDocumentation
- Batch-specific COA (assay, residual aniline, appearance)
- Safety Data Sheet (SDS)
- Dangerous-goods transport documents where applicable
- Third-party inspection on request
- Certificate of origin
What is 1,3-Diisopropyl-2-isothiocyanato-5-phenoxybenzene?
DIPPI is a benzene ring carrying isopropyl groups at the 1- and 3-positions, an isothiocyanate at the 2-position and a phenoxy ether at the 5-position, formula C₁₉H₂₁NOS. It is supplied as a light yellow solid or melt depending on grade and ambient temperature.
Every part of that structure is there for a reason. The isothiocyanate is the reactive group — it is attacked by amines to build thiourea linkages. The two isopropyl groups flanking it provide steric bulk that shapes the finished molecule's biological behaviour. The phenoxy ether is simply carried through unchanged.
In practice almost all commercial volume goes into diafenthiuron, the thiourea insecticide and acaricide, where DIPPI is condensed with a tert-butylamine to close out the molecule. It is a late-stage intermediate, which means buyers tend to care a great deal about its impurity profile.
Handling follows standard precautions for an aryl isothiocyanate. These compounds are irritating, often sensitising, and should be handled with chemical-resistant gloves, eye protection and good ventilation.
Why DIPPI specifically
- A late-stage intermediate. It carries the full carbon skeleton of the target active, so one condensation step completes the molecule.
- A clean reactive handle. The isothiocyanate reacts with amines directly to form thioureas without coupling catalysts or activators.
- Built-in steric bulk. The 2,6-diisopropyl substitution is designed into the molecule, not added later.
- Supply-chain leverage. Buying DIPPI rather than making it in-house removes a thiophosgene-type step from your own plant.
How DIPPI is Manufactured
The route builds the substituted aniline first and converts the amine to an isothiocyanate last — which is why the amine content of the finished product is the number that matters.
- Aniline preparation. 2,6-Diisopropyl-4-phenoxyaniline is prepared from 2,6-diisopropylaniline chemistry with the phenoxy group installed on the ring.
- Thiocarbonylation. The aniline is converted to the isothiocyanate using a thiocarbonyl transfer reagent under controlled conditions.
- Workup. Spent reagent and by-products are removed and the crude product is washed.
- Purification and release. Purified to the target assay, then assay, residual aniline and appearance are confirmed against specification before packing.
Typical Commercial Specification
Figures below are representative of commercial-grade DIPPI. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.
| Parameter | Typical Value |
|---|---|
| Appearance | Light yellow solid, melt or oil to grade |
| Assay | 97% min by GC |
| Residual aniline precursor | Trace levels to grade |
| Moisture | Low, to grade — isothiocyanates hydrolyse |
| Appearance after storage | Reported, as colour deepens with age |
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical formula | C₁₉H₂₁NOS |
| Molecular weight | 311.44 g/mol |
| Appearance | Light yellow solid or viscous melt |
| Boiling point | High — predicted above 400 °C at atmospheric pressure |
| Density | About 1.04 g/cm³ |
| Solubility | Soluble in dichloromethane, ethyl acetate, methanol; insoluble in water |
| Storage | Cool, sealed, under inert gas for long storage |
| Incompatibilities | Amines, alcohols, water, strong bases, strong oxidisers |
Behaviour in the process
The isothiocyanate group drives everything:
- Thiourea formation. Primary and secondary amines add directly across the N=C=S group to give substituted thioureas.
- Moisture sensitivity. Water hydrolyses the isothiocyanate back towards the amine — keep containers sealed and solvents dry.
- Steric hindrance. The flanking isopropyl groups slow the addition relative to an unhindered aryl isothiocyanate; expect to adjust temperature or time accordingly.
- Colour drift. The material deepens in colour on storage; this is normal and is not by itself an assay failure.
DIPPI and Related Intermediates
Choosing between these comes down to how much of the target skeleton you want delivered and which step you would rather not run in your own plant.
| Material | Reactive group | When it is the right choice |
|---|---|---|
| DIPPI | Aryl isothiocyanate | Diafenthiuron routes — one condensation from the finished active |
| 2,6-Diisopropylaniline | Free aromatic amine | Upstream routes where you build the phenoxy and isothiocyanate yourself |
| 2,6-Diisopropylphenyl isothiocyanate | Aryl isothiocyanate, no phenoxy | Ligand and fine-chemical routes that do not need the phenoxy ether |
| 2,6-Diisopropylphenyl isocyanate | Aryl isocyanate | Urea rather than thiourea chemistry |
Stated plainly: DIPPI is bought by people who want the thiophosgene-type chemistry done elsewhere and only the final condensation in their own plant.
Industries We Supply DIPPI To
This is a focused product with a focused customer base. What changes between buyers is scale, the impurity limits written into the specification and the registration documentation each requires.
Where DIPPI is Used
In downstream functionalisation
The chemistry is a single addition: an amine nitrogen attacks the central carbon of the N=C=S group and a thiourea forms. Because the ring is flanked by two isopropyl groups, that addition is slower than with an unhindered isothiocyanate — which is a process-development detail worth knowing before the first batch rather than after it.
Need a specific purity grade?
Tell us the purity grade you need, your downstream chemistry, the packing format you can receive and the annual quantity. We will come back with a price, a lead time and a sample COA.
Quality Control & Testing
Every lot is released against a batch-specific Certificate of Analysis, with residual aniline reported alongside the main assay because that is the impurity your registration dossier will ask about.
- Assay — by GC, the primary grade measure.
- Residual aniline precursor — reported because it competes in the condensation and carries into the active.
- Moisture — reported because water hydrolyses the isothiocyanate in storage.
- Appearance — reported as a freshness indicator, since colour deepens with age.
Common Process Problems & Likely Causes
| Symptom | Likely cause | What to check |
|---|---|---|
| Low conversion in the condensation | Hydrolysed isothiocyanate from moisture ingress | Moisture figure and how long the drum has been open |
| Aniline carryover in the active | Residual precursor in the incoming lot | Residual aniline figure on the COA |
| Slow reaction rate | Steric hindrance from the flanking isopropyl groups | Temperature and residence time in your condensation step |
| Darkened material on receipt | Age or heat exposure in transit | Lot age and storage conditions; confirm assay before rejecting |
Packaging, Storage & Shipping
- Standard packing. Sealed drums or lined bags, typically 25 – 200 kg net, with larger bulk formats on contract supply.
- Moisture protection. Keep containers tightly sealed and store under nitrogen where the material will sit before use.
- Temperature control. Store cool, dry and well ventilated, away from direct sun and heat.
- Material compatibility. Keep away from amines, alcohols, water, strong bases and strong oxidisers.
- Transport classification. Confirm the UN entry, class and packing group against your own current SDS before shipping.
Hazards & Safe Handling
Aryl isothiocyanates are irritating to skin, eyes and the respiratory tract and are frequently sensitising. Treat DIPPI accordingly and work from your own current SDS for the exact classification of your grade.
- Skin and eye contact. Chemical-resistant gloves and goggles are standard; rinse thoroughly and at length on contact.
- Sensitisation. Isothiocyanates can provoke allergic skin reactions — avoid repeated low-level exposure, not just splashes.
- Inhalation. Handle under local exhaust ventilation; avoid breathing vapour or aerosol during transfers.
- Environment. Harmful to aquatic life; avoid uncontrolled release to water and follow local effluent rules.
Regulatory & Compliance Notes
DIPPI is a specialty agrochemical intermediate. Because obligations differ by territory and use, the notes below are orientation rather than legal advice.
- GHS classification. Commonly classified for skin, eye and respiratory irritation and as a potential sensitiser; the SDS carries the full hazard statements for your grade.
- Chemical inventories. Inventory status varies by territory for intermediates of this kind — confirm before import, particularly for commercial quantities.
- Agrochemical registration. Where this feeds a registered active, your dossier will specify impurity limits. Tell us those limits at enquiry rather than after the first delivery.
- HS code. Commonly declared under the organo-sulphur compounds heading; confirm the exact tariff line with your customs broker for your jurisdiction.
We Supply DIPPI Worldwide
Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship 1,3-Diisopropyl-2-isothiocyanato-5-phenoxybenzene from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.
- Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
- Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
- Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
- Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.
Buying DIPPI from Chelora
We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the assay and residual-aniline grade your registration requires, the packing format, and the quantity you are buying.
- Documentation on every lot. Batch-specific COA with assay and impurity breakdown, plus the current SDS.
- Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
- Quantities. Trial quantities through to larger bulk shipments on contract supply.
- Inspection. Independent third-party inspection available at loading when the contract requires it.
- Related intermediates. 2,6-Diisopropylaniline and other agrochemical building blocks alongside this product from one supplier.
How ordering works
- Send the enquiry. Assay grade, residual-aniline limit, quantity, destination port and the Incoterm you buy on.
- We quote. Price, lead time, packing format and a sample COA, normally within one working day.
- Qualify the supply. For first orders or registered-active applications, we share the analysis so your technical team can sign off before you commit.
- Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
- Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.
DIPPI — Common Questions
The questions our technical desk is asked most often about 1,3-Diisopropyl-2-isothiocyanato-5-phenoxybenzene. If yours isn't here, call or email and you will reach someone who knows the chemistry.
What is the CAS number of DIPPI?
The CAS number for 1,3-Diisopropyl-2-isothiocyanato-5-phenoxybenzene (DIPPI) is 80058-93-1. Its molecular formula is C₁₉H₂₁NOS with a molecular weight of 311.44 g/mol.
What is DIPPI used for?
Its principal commercial use is as the late-stage intermediate in diafenthiuron manufacture, where it is condensed with an amine to form the thiourea active. It also serves more generally in hindered thiourea synthesis.
What does the abbreviation DIPPI stand for?
It is the industry shorthand for the diisopropyl phenoxyphenyl isothiocyanate structure, also written as 2,6-diisopropyl-4-phenoxyphenyl isothiocyanate.
How does the isothiocyanate group react?
Amines add directly across the N=C=S group to give substituted thioureas, with no coupling catalyst needed. The flanking isopropyl groups make that addition slower than with an unhindered isothiocyanate.
How is DIPPI manufactured?
By preparing 2,6-diisopropyl-4-phenoxyaniline and then converting that amine to the isothiocyanate with a thiocarbonyl transfer reagent, followed by workup and purification.
Is DIPPI hazardous?
Aryl isothiocyanates are irritating to skin, eyes and the respiratory tract and are often sensitising. Refer to the current SDS for your grade for the complete hazard classification.
What is the transport classification?
The correct entry depends on the grade and its physical form. Confirm the UN number, class and packing group against your own current SDS before relying on it for shipping documentation.
Why does my material look darker than the last lot?
Colour deepens with age and heat exposure in this class of compound. Judge the lot on its assay and residual-aniline figures rather than on appearance alone.
Which impurity matters most downstream?
Unconverted aniline precursor. It competes for your amine in the condensation step and carries into the finished active's impurity profile, which is where a registration dossier will look.
How should DIPPI be stored?
In tightly sealed containers, cool, dry and well ventilated, ideally under nitrogen for long storage, away from amines, alcohols, water and strong oxidisers.
What purity grades do you offer?
Standard commercial grade is 97% minimum by GC, with residual aniline, moisture and appearance reported on the COA. Tighter grades are available against a stated specification.
What packing sizes and order quantities are available?
Sealed drums or lined bags, typically 25–200 kg net, with larger bulk formats available on contract supply. Orders run from trial quantities up to repeat bulk loads.
Ready to source DIPPI?
Send us your purity requirement and annual volume. You will get a price, a realistic lead time and a sample COA from someone who understands what the material has to do in your process — delivered anywhere in the world.