ortho-Fluoroaniline 2-Fluoroaniline · CAS 348-54-9
Chelora Chemicals is a supplier of ortho-Fluoroaniline, the single-fluorine aniline isomer used as a building block in dye, pharmaceutical and agrochemical synthesis wherever a fluorine adjacent to the reactive amine is needed without the complexity of a multi-fluorinated ring. Every consignment leaves with a batch-specific COA and the current SDS.
Also known as: 2-Fluoroaniline, o-Fluoroaniline
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Price, lead time and a sample COA for ortho-Fluoroaniline, usually within one working day. We ship worldwide.
Request a Quote Email the DeskDocumentation
- Batch-specific COA (assay, colour, water content)
- Safety Data Sheet (SDS)
- Dangerous-goods transport documents, confirmed to your SDS
- Third-party inspection on request
- Certificate of origin
What is ortho-Fluoroaniline?
ortho-Fluoroaniline, also known as 2-fluoroaniline, is a benzene ring carrying a single fluorine atom adjacent to a primary amine group, formula C₆H₆FN. It is supplied as a clear to pale yellow liquid.
Its value as an intermediate comes from the fluorine's modest but useful electronic effect on the aniline nitrogen, combined with the simplicity of working with only a single fluorine rather than a multi-fluorinated system. It is used across dye, pharmaceutical and agrochemical synthesis wherever this specific substitution — fluorine ortho to the amine — is the structural requirement.
Commercially it is produced by reducing ortho-fluoronitrobenzene, typically by catalytic hydrogenation, or via diazotisation/fluorination (Balz-Schiemann or Halex-type) routes starting from ortho-chloroaniline or a related precursor.
Handling follows standard precautions for a fluorinated aniline — chemical-resistant gloves and eye protection, adequate ventilation, and storage away from incompatible materials such as strong oxidisers. Like most anilines, it darkens with prolonged exposure to air and light.
Why ortho-Fluoroaniline specifically
- A single, well-defined fluorine substitution. The ortho-fluorine gives a useful electronic effect on the amine without the cost or complexity of multiple fluorines.
- Dye intermediate. Used in selected dye-intermediate syntheses requiring this specific substitution pattern.
- Pharma and agro building block. A starting material for pharmaceutical and agrochemical intermediate routes needing a fluorine ortho to the aniline nitrogen.
- Simpler handling than polyfluorinated anilines. A single fluorine keeps the molecule's properties closer to unsubstituted aniline, which some routes specifically want.
How ortho-Fluoroaniline is Manufactured
ortho-Fluoroaniline is produced either by reducing ortho-fluoronitrobenzene, or by diazotisation/fluorination routes starting from ortho-chloroaniline or a related aromatic amine precursor.
- Fluorine introduction or nitro reduction. Either ortho-fluoronitrobenzene is reduced by catalytic hydrogenation, or a diazotisation/fluorination sequence installs the fluorine on an aniline precursor.
- Workup. The crude aniline is separated from catalyst, salts and by-products.
- Purification. The product is purified by distillation to the target assay specification.
- Quality release and packing. Assay, colour and water content are confirmed against specification before the batch is packed and released, typically under nitrogen to limit oxidation.
Typical Commercial Specification
Figures below are representative of commercial-grade ortho-fluoroaniline. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.
| Parameter | Typical Value |
|---|---|
| Appearance | Clear to pale yellow liquid |
| ortho-Fluoroaniline content | 99% min by GC assay |
| Colour | To grade; freshness indicator ahead of use |
| Water content | To grade, typically 0.2% max |
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical formula | C₆H₆FN |
| Molecular weight | 111.12 g/mol |
| Appearance | Clear to pale yellow liquid |
| Melting point | About -4 °C |
| Boiling point | About 174 – 176 °C |
| Density | About 1.153 g/mL at 25 °C |
| Flash point | About 71 °C |
| Incompatibilities | Strong oxidisers |
Behaviour in the process
ortho-Fluoroaniline's reactivity pattern is what dye, pharma and agro intermediate producers are buying:
- Amine reactivity. The free amine is available for acylation, diazotisation, or cyclisation chemistry.
- Oxidative sensitivity. Like many anilines, it darkens on prolonged exposure to air and light; store accordingly.
- Thermal stability. Stable under normal storage conditions away from strong oxidisers.
ortho-Fluoroaniline and Related Fluoroanilines
Choosing between fluoroaniline grades comes down to how many fluorines, and in what pattern, the target synthesis needs.
| Material | Substitution | When it is the right choice |
|---|---|---|
| ortho-Fluoroaniline | 2-F, 1-NH₂ | Routes needing only a single fluorine ortho to the amine |
| 2,6-Difluoroaniline | 2,6-diF, 1-NH₂ | Routes needing two fluorines in a symmetric pattern |
| 2,3,4-Trifluoroaniline | 2,3,4-triF, 1-NH₂ | Fluoroquinolone antibiotic synthesis needing three adjacent fluorines |
| meta-Chloroaniline | 3-Cl, 1-NH₂ | Routes needing a chlorine rather than a fluorine at this position |
Stated plainly: a synthesis that specifically calls for a single ortho-fluorine on the aniline ring needs this isomer — the difluoro- and trifluoro-anilines have substantially different electronic and steric properties.
Industries We Supply ortho-Fluoroaniline To
The same fluoroaniline feeds a dye-intermediate manufacturer and a pharmaceutical intermediate producer. What changes is the downstream chemistry and the documentation each requires.
Where ortho-Fluoroaniline is Used
In downstream functionalisation
ortho-Fluoroaniline's free amine is carried through acylation, diazotisation or cyclisation chemistry to build the target dye, pharma or agro intermediate. The single ortho-fluorine gives a defined electronic effect without the added cost and complexity of multi-fluorinated systems — often exactly why a route is designed around this material specifically rather than a more heavily fluorinated analogue.
Need a specific purity grade?
Tell us the purity grade you need, your downstream chemistry, the packing format you can receive and the annual quantity. We will come back with a price, a lead time and a sample COA.
Quality Control & Testing
Every lot is released against a batch-specific Certificate of Analysis, with colour reported alongside the main assay because anilines oxidise on storage and colour is a useful freshness indicator.
- ortho-Fluoroaniline content — by GC assay, the primary grade measure.
- Colour — reported because oxidation darkens anilines over time.
- Water content — measured because moisture can affect downstream reaction yield.
Common Process Problems & Likely Causes
| Symptom | Likely cause | What to check |
|---|---|---|
| Darkened material on receipt | Oxidation during storage or transit | Colour and age of the lot; storage conditions |
| Poor acylation or diazotisation yield | Moisture or oxidation by-products | Water content and colour on the COA |
| Off-shade dye product | Assay or colour-grade impurities | Assay and colour specification on the COA |
Packaging, Storage & Shipping
- Standard packing. Drums or jerricans, typically 25 – 200 kg net, with larger bulk formats on contract supply.
- Oxidation protection. Store under nitrogen where possible and keep containers tightly sealed to limit darkening.
- Temperature control. Store in a cool, dry, well-ventilated area away from direct sun, heat and ignition sources.
- Material compatibility. Avoid contact with strong oxidisers.
- Transport classification. Confirm the UN number and transport class against your own current SDS before shipping — published sources for this specific compound did not report a confirmed UN number at drafting time.
Hazards & Safe Handling
ortho-Fluoroaniline is a fluorinated aniline and should be handled with the standard precautions that apply to this class of compound. Refer to the current SDS for your grade for the complete hazard classification.
- Skin and eye contact. Chemical-resistant gloves and goggles are standard practice for fluorinated anilines; rinse thoroughly with water on contact.
- Inhalation. Use adequate ventilation when handling, given the material's volatility.
- PPE. Chemical-resistant gloves, safety goggles and, where vapour exposure is a concern, a suitable respirator.
- Fire. Keep away from ignition sources given the reported flash point; store accordingly.
Regulatory & Compliance Notes
ortho-Fluoroaniline is a registered specialty fluoroaromatic amine. Because obligations differ by territory and use, and because confirmed UN transport data for this compound was not found in public sources at drafting time, the notes below are orientation rather than legal advice.
- GHS classification. Refer to your supplier's current SDS for the full classification applicable to your grade.
- REACH and chemical inventories. Registered under EU REACH and listed on major chemical inventories.
- Dangerous goods transport. Confirm the UN number, transport class and packing group with your logistics/EHS team against your current SDS before shipping.
- HS code. Commonly declared under the aromatic amine derivatives heading; confirm the exact tariff line with your customs broker for your jurisdiction.
We Supply ortho-Fluoroaniline Worldwide
Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship ortho-Fluoroaniline from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.
- Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
- Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
- Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
- Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.
Buying ortho-Fluoroaniline from Chelora
We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the purity grade your application needs, the packing format, and the quantity you are buying — and confirming transport classification with you before the first shipment.
- Documentation on every lot. Batch-specific COA with assay and colour data, plus the current SDS.
- Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
- Quantities. Trial quantities through to larger bulk shipments on contract supply.
- Inspection. Independent third-party inspection available at loading when the contract requires it.
- Related fluoroanilines. 2,6-Difluoroaniline, 2,3,4-trifluoroaniline and other fluoroaromatics alongside this product from one supplier.
How ordering works
- Send the enquiry. Purity grade, quantity, destination port and the Incoterm you buy on.
- We quote. Price, lead time, packing format and a sample COA, normally within one working day.
- Qualify the supply. For first orders or pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
- Confirm transport classification. We work with you and your logistics team to confirm the UN number and transport class for your lane.
- Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
- Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.
ortho-Fluoroaniline — Common Questions
The questions our technical desk is asked most often about ortho-Fluoroaniline. If yours isn't here, call or email and you will reach someone who knows the chemistry.
What is the CAS number of ortho-Fluoroaniline?
The CAS number for ortho-Fluoroaniline (2-Fluoroaniline) is 348-54-9, and its EC number is 206-062-8. Its molecular formula is C₆H₆FN with a molecular weight of 111.12 g/mol.
What is ortho-Fluoroaniline used for?
It is used as a building block in dye-intermediate, pharmaceutical and agrochemical synthesis requiring a single fluorine ortho to the aniline nitrogen.
Do you supply ortho-Fluoroaniline worldwide?
Yes. Chelora Chemicals supplies and exports ortho-Fluoroaniline worldwide — across Asia Pacific, Europe, the Middle East, Africa and the Americas, as well as throughout India. Every consignment carries the COA and SDS.
How is ortho-Fluoroaniline manufactured?
Either by reducing ortho-fluoronitrobenzene by catalytic hydrogenation, or by a diazotisation/fluorination route starting from ortho-chloroaniline or a related precursor.
Is ortho-Fluoroaniline hazardous?
It is a fluorinated aniline handled with standard precautions for this class of compound. Refer to the current SDS for your grade for the complete hazard classification.
What is the UN number and transport classification?
A reliably confirmed, compound-specific UN number was not found in public sources at drafting time. Confirm transport classification against your own current SDS before relying on it for shipping documentation.
What are the melting point, boiling point and density?
Typical figures are a melting point around -4 °C, a boiling point of 174 – 176 °C, and a density around 1.153 g/mL at 25 °C. Confirm against your own supplier's COA for batch-specific figures.
How does it differ from 2,6-difluoroaniline?
ortho-Fluoroaniline carries a single fluorine; 2,6-difluoroaniline carries two fluorines symmetrically placed around the amine. They give different electronic properties and are not interchangeable.
How should ortho-Fluoroaniline be stored?
In sealed containers, ideally under nitrogen, cool, dry and away from direct sun, heat, ignition sources and strong oxidisers. Like most anilines it can darken on prolonged exposure to air and light.
What purity grades do you offer?
Standard commercial grade is 99% minimum by GC assay, with colour and water content reported on the COA.
What packing sizes and order quantities are available?
Drums or jerricans, typically 25–200 kg net, with larger bulk formats available on contract supply. Orders run from trial quantities up to repeat bulk loads.
Ready to source ortho-Fluoroaniline?
Send us your purity requirement and annual volume. You will get a price, a realistic lead time and a sample COA from someone who understands what the material has to do in your process — delivered anywhere in the world.