2-Bromo-4-fluoroacetanilide 2'-Bromo-4'-fluoroacetanilide · CAS 1009-22-9
Chelora Chemicals is a supplier of 2-Bromo-4-fluoroacetanilide, the protected bromo-fluoro aniline used as a cross-coupling and cyclisation substrate in pharmaceutical and agrochemical synthesis. The acetyl group protects the nitrogen while the bromine does the work. Every consignment leaves with a batch-specific COA and the current SDS.
Also known as: 2'-Bromo-4'-fluoroacetanilide, N-(2-Bromo-4-fluorophenyl)acetamide, N-Acetyl-2-bromo-4-fluoroaniline
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Price, lead time and a sample COA for 2-Bromo-4-fluoroacetanilide, usually within one working day. We ship worldwide.
Request a Quote Email the DeskDocumentation
- Batch-specific COA (assay, melting range, isomer purity)
- Safety Data Sheet (SDS)
- NMR / IR structure confirmation on request
- Third-party inspection on request
- Certificate of origin
What is 2-Bromo-4-fluoroacetanilide?
2-Bromo-4-fluoroacetanilide is 4-fluoroaniline with its nitrogen acetylated and a bromine placed ortho to that nitrogen, formula C₈H₇BrFNO. It is supplied as a white to off-white crystalline powder melting around 117 – 119 °C.
The molecule is best understood as three parts doing three different jobs. The acetamido group protects the nitrogen and directs where the bromine lands. The bromine is the reactive handle for palladium-catalysed coupling or for ring-closing chemistry. The fluorine stays put, because the finished molecule is meant to carry it.
That division of labour is why it is bought rather than made in-house: getting the bromine onto the right position without over-brominating or touching the fluorine is the part that is worth outsourcing.
It is a stable solid under ordinary storage, harmful if swallowed and irritating to skin and eyes, and does not carry the handling burden of a free aniline.
Why 2-Bromo-4-fluoroacetanilide specifically
- A protected nitrogen. The acetyl group keeps the amine out of the way during coupling and is removed cleanly by hydrolysis when it is no longer needed.
- An orthogonal halogen pair. Bromine reacts in cross-coupling under conditions that leave the ring fluorine untouched.
- Defined regiochemistry. Bromine ortho to nitrogen, fluorine para — a substitution pattern that would be awkward to reach by direct halogenation of the free aniline.
- A stable, easy-handling solid. Unlike the free bromo-fluoro aniline, it does not darken or oxidise in storage.
How 2-Bromo-4-fluoroacetanilide is Manufactured
The commercial route protects first and brominates second, which is what fixes the regiochemistry.
- Acetylation. 4-Fluoroaniline is acetylated, typically with acetic anhydride, to give 4-fluoroacetanilide.
- Bromination. The acetanilide is brominated under controlled conditions so the bromine enters ortho to the acetamido group.
- Isolation. The product is quenched, filtered and washed free of inorganic residues and spent brominating agent.
- Purification and release. Recrystallisation to the target assay, then assay, melting range and isomer purity are confirmed before packing.
Typical Commercial Specification
Figures below are representative of commercial-grade 2-bromo-4-fluoroacetanilide. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.
| Parameter | Typical Value |
|---|---|
| Appearance | White to almost white powder or crystal |
| Assay | 98% min by GC |
| Melting range | 116 – 120 °C |
| Isomer and dibromo impurities | Trace levels to grade |
| Structure confirmation | NMR / IR conform to structure |
| Loss on drying | Low, to grade |
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical formula | C₈H₇BrFNO |
| Molecular weight | 232.05 g/mol |
| Appearance | White to off-white crystalline solid |
| Melting point | 117 – 119 °C |
| Flash point | Above 110 °C |
| Solubility | Soluble in methanol and common organic solvents; poorly soluble in water |
| Storage | Sealed, dry, room temperature |
| Incompatibilities | Strong oxidisers, strong bases |
Behaviour in the process
What buyers are actually paying for is a reliable handle in the right place:
- Cross-coupling. The aryl bromide takes part in Suzuki, Buchwald–Hartwig, Heck and related palladium-catalysed chemistry.
- Deprotection on demand. The acetamide is hydrolysed under acid or base when the free aniline is wanted later in the route.
- Ring closure. The ortho bromine and the amide nitrogen together set up benzothiazole, indole and quinoline-type cyclisations.
- Storage stability. A dry, stable solid — no nitrogen blanket or antioxidant required.
2-Bromo-4-fluoroacetanilide and Related Intermediates
Choosing between these comes down to whether you want the nitrogen protected and which halogen the route needs to activate.
| Material | Nitrogen state | When it is the right choice |
|---|---|---|
| 2-Bromo-4-fluoroacetanilide | Acetyl-protected | Cross-coupling or cyclisation where a free amine would interfere |
| 2-Bromo-4-fluoroaniline | Free amine | Routes that need the free nitrogen immediately and tolerate it |
| ortho-Fluoroaniline | Free amine | Routes needing only a ring fluorine, no coupling handle |
| 2,4-Dinitrofluorobenzene | No nitrogen on ring | SNAr displacement chemistry rather than cross-coupling |
Stated plainly: if your palladium chemistry would be poisoned or misdirected by a free aniline nitrogen, the protected acetanilide is the version to buy, and you deprotect later.
Industries We Supply 2-Bromo-4-fluoroacetanilide To
The same intermediate feeds an API process chemist and an agrochemical discovery team. What changes is the scale, the impurity profile that matters and the documentation each requires.
Where 2-Bromo-4-fluoroacetanilide is Used
In downstream functionalisation
A typical sequence couples at the bromine first, then hydrolyses the acetamide to unmask the aniline for the next step — amide formation, diazotisation or cyclisation. The fluorine is a passenger throughout, which is the point: it is there because the finished molecule needs it, not because it does anything in the chemistry.
Need a specific purity grade?
Tell us the purity grade you need, your downstream chemistry, the packing format you can receive and the annual quantity. We will come back with a price, a lead time and a sample COA.
Quality Control & Testing
Every lot is released against a batch-specific Certificate of Analysis, with bromination-related impurities reported alongside the main assay because those are what carry through into your coupling step.
- Assay — by GC, the primary grade measure.
- Isomer and dibromo impurities — reported because they consume catalyst and generate hard-to-remove by-products.
- Melting range — a practical purity check on a crystalline solid.
- NMR / IR — structure confirmation available on request for pharmaceutical qualification.
Common Process Problems & Likely Causes
| Symptom | Likely cause | What to check |
|---|---|---|
| Poor coupling conversion | Catalyst poisoning or inhibitor carryover | Residual solvent and impurity profile on the COA |
| Double-coupled by-product | Dibrominated impurity in the feed | Dibromo figure on the COA |
| Regio-isomeric product | Positional isomer from the bromination step | Isomer purity figure on the COA |
| Low melting point on receipt | Residual solvent or moisture | Loss on drying and melting range |
Packaging, Storage & Shipping
- Standard packing. Fibre drums, HDPE drums or double-lined bags, typically 1 – 50 kg net, with larger formats on contract supply.
- Moisture protection. Keep containers sealed; the material is hygroscopic enough that loss on drying can drift in an open drum.
- Temperature control. Store at room temperature in a cool, dry, well-ventilated area away from direct sun.
- Material compatibility. Avoid contact with strong oxidisers and strong bases.
- Transport classification. Normally not regulated for transport — confirm against your own current SDS before shipping.
Hazards & Safe Handling
2-Bromo-4-fluoroacetanilide is harmful if swallowed and irritating to skin and eyes. Standard good laboratory and plant practice for a fine-chemical powder applies throughout handling.
- Skin and eye contact. Gloves and safety goggles are standard; rinse thoroughly with water on contact and seek advice if eye irritation persists.
- Dust. Avoid generating dust when charging reactors; use local exhaust ventilation.
- PPE. Chemical-resistant gloves, safety goggles and a dust mask where airborne powder is a concern.
- Hygiene. Do not eat, drink or smoke when handling; wash hands thoroughly afterwards.
Regulatory & Compliance Notes
2-Bromo-4-fluoroacetanilide is a specialty fine-chemical intermediate. Because obligations differ by territory and use, the notes below are orientation rather than legal advice.
- GHS classification. Classified as harmful if swallowed and as a skin and eye irritant (Signal word: Warning); the SDS carries the full hazard statements for your grade.
- Chemical inventories. Inventory status varies by territory for specialty building blocks of this kind — confirm before import, particularly for commercial rather than R&D quantities.
- Dangerous goods transport. Normally not regulated. Confirm with your logistics/EHS team against your current SDS before shipping.
- HS code. Commonly declared under the cyclic amides heading; confirm the exact tariff line with your customs broker for your jurisdiction.
We Supply 2-Bromo-4-fluoroacetanilide Worldwide
Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship 2-Bromo-4-fluoroacetanilide from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.
- Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
- Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
- Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
- Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.
Buying 2-Bromo-4-fluoroacetanilide from Chelora
We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the assay and impurity-profile grade your application needs, the packing format, and the quantity you are buying.
- Documentation on every lot. Batch-specific COA with assay and impurity breakdown, plus the current SDS.
- Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
- Quantities. Laboratory and trial quantities through to larger bulk shipments on contract supply.
- Inspection. Independent third-party inspection available at loading when the contract requires it.
- Related intermediates. Fluoroanilines, dinitro-fluoro aromatics and other halogenated building blocks alongside this product from one supplier.
How ordering works
- Send the enquiry. Assay grade, impurity limits, quantity, destination port and the Incoterm you buy on.
- We quote. Price, lead time, packing format and a sample COA, normally within one working day.
- Qualify the supply. For first orders or pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
- Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
- Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.
2-Bromo-4-fluoroacetanilide — Common Questions
The questions our technical desk is asked most often about 2-Bromo-4-fluoroacetanilide. If yours isn't here, call or email and you will reach someone who knows the chemistry.
What is the CAS number of 2-Bromo-4-fluoroacetanilide?
The CAS number for 2-Bromo-4-fluoroacetanilide is 1009-22-9, and its EC number is 600-141-3. Its molecular formula is C₈H₇BrFNO with a molecular weight of 232.05 g/mol.
What is 2-Bromo-4-fluoroacetanilide used for?
It is used as a cross-coupling substrate and cyclisation precursor in pharmaceutical and agrochemical synthesis, where the bromine provides the reactive handle and the acetyl group keeps the nitrogen protected.
Why is the nitrogen acetylated?
The acetyl group directs the bromine to the ortho position during manufacture and then keeps the amine from interfering with palladium catalysis. It is hydrolysed off later when the free aniline is needed.
Can I deprotect it to the free aniline?
Yes. The acetamide is hydrolysed under acidic or basic conditions to give 2-bromo-4-fluoroaniline when your route calls for the free nitrogen.
How is 2-Bromo-4-fluoroacetanilide manufactured?
By acetylating 4-fluoroaniline to the acetanilide, then brominating under controlled conditions so the bromine enters ortho to the acetamido group, followed by recrystallisation.
Is 2-Bromo-4-fluoroacetanilide hazardous?
It is harmful if swallowed and irritating to skin and eyes. Refer to the current SDS for your grade for the complete hazard classification.
Is it classified as dangerous goods for transport?
Normally it is not regulated for transport. Confirm this against your own current SDS before relying on it for shipping documentation, particularly for air freight.
What is the melting point?
Typically 117 – 119 °C, with commercial specifications usually written as a 116 – 120 °C range. Confirm against your own supplier's COA for batch-specific figures.
Which impurities matter most downstream?
Dibrominated by-product and positional isomers from the bromination step. Both consume catalyst and generate by-products that are awkward to separate later, so ask for those figures on the COA.
How should 2-Bromo-4-fluoroacetanilide be stored?
Sealed, dry and at room temperature, in a cool well-ventilated area away from direct sun, strong oxidisers and strong bases.
What purity grades do you offer?
Standard commercial grade is 98% minimum by GC, with melting range and bromination-related impurities reported on the COA. NMR and IR confirmation is available on request.
What packing sizes and order quantities are available?
Fibre drums, HDPE drums or double-lined bags, typically 1–50 kg net, with larger formats available on contract supply. Orders run from laboratory quantities up to repeat bulk loads.
Ready to source 2-Bromo-4-fluoroacetanilide?
Send us your purity requirement and annual volume. You will get a price, a realistic lead time and a sample COA from someone who understands what the material has to do in your process — delivered anywhere in the world.