2-Bromo-4-fluoroacetanilide
A high-purity halogenated acetanilide supplied for pharmaceutical intermediate synthesis, cross-coupling chemistry, and heterocycle construction.
What is 2-Bromo-4-fluoroacetanilide?
2-Bromo-4-fluoroacetanilide — systematically N-(2-bromo-4-fluorophenyl)acetamide — is a white to off-white crystalline solid carrying a bromine, a fluorine, and an acetylated amine on one ring.
The acetyl group is doing deliberate work. It protects the aniline nitrogen so it cannot interfere in subsequent chemistry, and it directs where further substitution occurs. That leaves the bromine free as a coupling handle while the fluorine stays put as a permanent feature of the target molecule.
At Chelora Chemicals, 2B4FA is crystallised and refined with isomer content, melting range, and moisture held to specification for pharmaceutical intermediate use.
- Appearance
- White to off-white crystalline powder
- Odour
- Odourless to faint
- Solubility
- Slightly soluble in water; soluble in alcohols and polar organics
- Function
- Chemical intermediate
- Grade
- High purity / pharma intermediate
Formula diagram
Protected aniline with bromine and fluorine handles
- Molecular formulaC8H7BrFNO
- Molecular weight232.05 g/mol
- IUPAC nameN-(2-Bromo-4-fluorophenyl)acetamide
- Functional groupsAmide, aryl bromide, aryl fluoride
- CAS number1009-22-9
Technical product information
Standard specification for Chelora Chemicals' high-purity pharma-intermediate grade 2-Bromo-4-fluoroacetanilide. Custom-grade and bulk specifications are available on request.
| Chemical name | 2-Bromo-4-fluoroacetanilide |
|---|---|
| Synonyms | 2B4FA, N-(2-Bromo-4-fluorophenyl)acetamide, 2'-Bromo-4'-fluoroacetanilide |
| CAS number | 1009-22-9 |
| Molecular formula | C8H7BrFNO |
| Molecular weight | 232.05 g/mol |
| Assay (HPLC purity) | ≥ 98.0% |
| Appearance | White to off-white crystalline powder |
| Melting point | 110–114°C |
| Isomer content | ≤ 0.5% |
| Moisture | ≤ 0.5% |
| Residue on ignition | ≤ 0.1% |
| Packaging | 5 kg, 25 kg & 50 kg drums |
| Shelf life | 24 months from date of manufacture |
Applications of 2-Bromo-4-fluoroacetanilide
Pharmaceutical intermediates
A building block in API and development compound synthesis where a protected halogenated aniline is required.
Cross-coupling chemistry
The bromine serves as the handle for Suzuki, Buchwald, and related palladium-catalysed coupling.
Heterocyclic synthesis
Cyclised to build indoles, benzimidazoles, and related fused ring systems.
Agrochemical intermediates
Used in crop-protection routes needing a halogenated acetanilide core.
Deprotection routes
Hydrolysed to 2-bromo-4-fluoroaniline where the free amine is needed downstream.
Custom synthesis
Supplied as a research and contract manufacturing building block.
Why choose Chelora Chemicals
Every batch of 2-Bromo-4-fluoroacetanilide is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
HPLC assay controlled at ≥98% with isomer content and melting range verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 5 kg to 50 kg drums, with laboratory samples for development work.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly closed original packaging in a cool, dry, well-ventilated store.
- 02Protect from moisture — the amide hydrolyses slowly under humid or acidic conditions.
- 03Keep away from heat, ignition sources, and direct sunlight.
- 04Segregate from strong acids, strong bases, and strong oxidising agents.
- 05Keep drums sealed and palletised, and re-seal opened packaging promptly.
- 06Prevent release to drains, surface water, and soil.
Handling precautions
2B4FA is harmful if swallowed and causes skin and eye irritation. It is for industrial use by trained personnel only.
Control dust during drum emptying, sieving, and charging, and use local exhaust ventilation at transfer points.
Use chemical-resistant gloves, coveralls, and eye protection, and avoid breathing dust.
Deprotection with strong acid or base is exothermic and requires controlled addition and cooling at scale.
Refer to the full Safety Data Sheet for exposure limits, spill response, and first-aid measures before use.
Frequently asked questions
What is 2-Bromo-4-fluoroacetanilide used for?
It is a pharmaceutical and agrochemical intermediate, used where a protected aniline with a bromine coupling handle and a fixed fluorine is needed. It is also cyclised into fused heterocycles.
Why is the aniline acetylated rather than left free?
A free aromatic amine is nucleophilic enough to interfere in subsequent steps and can poison metal catalysts. Acetylation masks it, moderates the ring's reactivity, and directs where further substitution takes place. The acetyl group is removed later by hydrolysis.
Why bromine rather than chlorine on this position?
The carbon–bromine bond undergoes oxidative addition to palladium far more readily than carbon–chlorine, so it couples under milder conditions and with a wider range of catalysts. Cost is the trade-off.
Does the fluorine react?
Not under normal coupling conditions. On this ring, without strong activating groups, the carbon–fluorine bond is stable, so it survives into the final molecule where it contributes metabolic stability.
How is the acetyl group removed?
By hydrolysis with acid or base, giving 2-bromo-4-fluoroaniline. The step is exothermic at scale and needs controlled addition and cooling.
Is it soluble in water?
Only slightly. It dissolves in alcohols, acetone, DMF, DMSO, and ethyl acetate, which covers the solvents used in most coupling and cyclisation routes.
Why is moisture specified?
The amide hydrolyses slowly in the presence of water, particularly with acid or base present. Controlling moisture protects assay through the shelf life.
What purity do you supply?
Standard grade is supplied at a minimum HPLC assay of 98% with isomer content at or below 0.5% and moisture at or below 0.5%. Tighter specifications can be manufactured for regulated pharmaceutical use.
What packaging sizes are available?
5 kg, 25 kg, and 50 kg drums, with laboratory and pilot samples available for development and qualification work.
Can you supply to a regulated pharmaceutical specification?
Yes. Isomer limits, residual solvent, metals, and related substances can be tightened to a customer specification sheet with supporting analytical documentation.
Do you provide a Certificate of Analysis?
Yes. Every batch is dispatched with a Certificate of Analysis and Safety Data Sheet covering HPLC assay, melting range, isomer content, moisture, and appearance.