2,4-Dichlorofluorobenzene
A high-purity mixed-halogen aromatic supplied for pharmaceutical, agrochemical, dye, and liquid crystal intermediate synthesis.
What is 2,4-Dichlorofluorobenzene?
2,4-Dichlorofluorobenzene — systematically 2,4-dichloro-1-fluorobenzene — is a colourless to pale yellow liquid carrying two chlorines and one fluorine in an unsymmetrical arrangement around the ring.
The three halogens are not equivalent, and that is the point. The chlorines are the reactive handles for coupling and substitution chemistry, while the fluorine generally survives intact into the finished molecule, where it contributes metabolic stability and lipophilicity.
At Chelora Chemicals, 24DCFB is distilled to high assay with isomer content and moisture controlled, since the closely related dichlorofluorobenzene isomers are difficult to separate once carried into a downstream step.
- Appearance
- Colourless to pale yellow liquid
- Odour
- Characteristic aromatic
- Solubility
- Insoluble in water; soluble in most organic solvents
- Function
- Chemical intermediate
- Grade
- High purity
Formula diagram
Fluorine with chlorines at the ortho and para positions
- Molecular formulaC6H3Cl2F
- Molecular weight164.99 g/mol
- IUPAC name2,4-Dichloro-1-fluorobenzene
- Functional groupsAryl chloride, aryl fluoride
- CAS number1435-48-9
Technical product information
Standard specification for Chelora Chemicals' high-purity intermediate 2,4-Dichlorofluorobenzene. Custom-grade and bulk specifications are available on request.
| Chemical name | 2,4-Dichlorofluorobenzene |
|---|---|
| Synonyms | 24DCFB, 2,4-Dichloro-1-fluorobenzene, 1,3-Dichloro-4-fluorobenzene |
| CAS number | 1435-48-9 |
| Molecular formula | C6H3Cl2F |
| Molecular weight | 164.99 g/mol |
| Assay (GC purity) | ≥ 99.0% |
| Appearance | Clear, colourless to pale yellow liquid |
| Density (20°C) | 1.38–1.42 g/cm³ |
| Boiling point | 172–174°C |
| Freezing point | below 0°C |
| Flash point | ≈ 62°C (closed cup) |
| Isomer content | ≤ 0.5% |
| Water content | ≤ 0.1% |
| Packaging | 25 kg & 200 kg drums |
| Shelf life | 24 months in sealed original packaging |
Applications of 2,4-Dichlorofluorobenzene
Pharmaceutical intermediates
Used to build halogenated aromatic cores in API and development compound synthesis.
Agrochemical intermediates
Introduces a mixed-halogen aromatic fragment into crop-protection actives.
Cross-coupling chemistry
The chlorines serve as handles for palladium-catalysed coupling and metalation routes.
Liquid crystal materials
Feeds fluorinated intermediates used in display-grade material manufacture.
Dye intermediates
Applied in halogenated colour intermediates requiring both chlorine and fluorine.
Custom synthesis
Supplied as a research and contract manufacturing building block.
Why choose Chelora Chemicals
Every batch of 2,4-Dichlorofluorobenzene is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
GC assay controlled at ≥99% with isomer profile and low moisture verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 25 kg drums to 200 kg drums, with laboratory samples for development work.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly sealed original containers in a cool, dry, well-ventilated store.
- 02Keep away from heat, sparks, and open flame — the flash point is around 62°C.
- 03Protect from moisture, which matters for downstream metalation and coupling chemistry.
- 04Segregate from strong oxidising agents, strong bases, and active metals.
- 05Use compatible containers: glass, stainless steel, or lined steel, blanketed with nitrogen where practical.
- 06Earth and bond containers and lines during transfer, and bund all bulk storage.
Handling precautions
The product is a combustible liquid. Eliminate ignition sources and control static during transfer.
It is harmful if swallowed or inhaled and causes skin, eye, and respiratory irritation. Chemical-resistant gloves, eye protection, and adequate ventilation are required.
Chlorinated and fluorinated aromatics can decompose in a fire to produce hydrogen chloride, hydrogen fluoride, and other hazardous combustion products. Fire-fighters require full breathing apparatus.
Avoid release to the environment and contain all spills with inert absorbent for licensed disposal.
Refer to the full Safety Data Sheet for exposure limits, fire-fighting measures, spill response, and first-aid information before use.
Frequently asked questions
What is 2,4-Dichlorofluorobenzene used for?
It is an intermediate for pharmaceutical, agrochemical, dye, and liquid crystal materials, valued for offering two chemically distinct halogen handles on one aromatic ring.
How many chlorines and fluorines does it contain?
Two chlorines and one fluorine: formula C6H3Cl2F, molecular weight 164.99. This is worth confirming on any enquiry, because the similar-sounding chlorodifluorobenzenes have the reverse composition and a different molecular weight.
What is its correct systematic name?
2,4-Dichloro-1-fluorobenzene, also written 1,3-dichloro-4-fluorobenzene depending on which substituent the numbering starts from. Both appear in catalogues for the same CAS number, 1435-48-9.
How does it differ from 2,6-dichlorofluorobenzene?
They are isomers sharing formula C6H3Cl2F and weight 164.99, but the 2,6 isomer places both chlorines beside the fluorine and melts around 35°C, while the 2,4 isomer is a liquid at room temperature. They give different substitution patterns downstream and are not interchangeable.
Why do the chlorines react while the fluorine does not?
Carbon–chlorine bonds are weaker and more polarisable, so they undergo oxidative addition and metalation far more readily. Without strong activating groups on the ring the carbon–fluorine bond is essentially inert.
Is it soluble in water?
No. It is practically insoluble in water and readily soluble in THF, ether, toluene, and most solvents used for coupling chemistry.
What purity do you supply?
Standard grade is supplied at a minimum GC assay of 99% with isomer content at or below 0.5% and water at or below 0.1%. Tighter isomer, metals, and colour specifications can be manufactured for pharmaceutical intermediate use.
Why is isomer content specified so carefully?
The dichlorofluorobenzene isomers have very similar boiling points, so any that carry into a downstream reaction produce closely related products that are hard to separate. Controlling them at this stage is far cheaper.
What packaging sizes are available?
25 kg and 200 kg drums, with laboratory and pilot samples available for development and qualification work.
How should it be stored?
In sealed original containers in a cool, dry, ventilated store away from ignition sources and moisture. Nitrogen blanketing is recommended for opened containers.
Do you provide a Certificate of Analysis?
Yes. Every batch is dispatched with a Certificate of Analysis and Safety Data Sheet covering GC assay, isomer content, density, water content, and appearance.