4-Fluoro-N-isopropylaniline N-Isopropyl-4-fluoroaniline · CAS 70441-63-3

What is 4-Fluoro-N-isopropylaniline?

4-Fluoro-N-isopropylaniline is a fluorinated secondary aromatic amine: a benzene ring carrying a fluorine at the 4-position and an isopropyl-substituted amine nitrogen, formula C₉H₁₂FN. It is typically supplied as a colourless to pale yellow liquid with a characteristic aromatic amine odour.

Its value as an intermediate comes from combining two features in one molecule: the fluorine substituent, which many fluorinated pharmaceutical and agrochemical actives require, and the N-isopropyl group, which is carried through directly into the target molecule's structure without further N-alkylation steps.

Commercially, it is produced by reductive N-alkylation of 4-fluoroaniline with acetone, or by direct N-alkylation with an isopropyl halide, under conditions that control over-alkylation to the tertiary amine.

As a secondary aromatic amine, it should be handled under standard amine-handling precautions. Public hazard and transport classification data for this specific compound is limited, so we supply the current SDS with every consignment and recommend confirming your own transport classification against it rather than against general aniline-class assumptions.

Why 4-Fluoro-N-isopropylaniline specifically

• A pre-built N-isopropyl fragment. Saves a separate N-alkylation step in routes where the target molecule needs this exact substituent on the amine nitrogen.
• A fluorinated aromatic building block. The 4-fluoro substitution is carried through into fluorinated pharmaceutical and agrochemical actives that specifically require it.
• Research and custom-synthesis utility. A convenient reagent for introducing this exact fluoroaniline fragment into a target molecule.
• The specific substitution pattern needed. Para-fluorine plus N-isopropyl substitution is a fixed combination; routes built around it need this exact molecule rather than a related fluoroaniline.

How 4-Fluoro-N-isopropylaniline is Manufactured

4-Fluoro-N-isopropylaniline is made through a controlled N-alkylation sequence starting from 4-fluoroaniline, so supply tracks installed fluoroaniline and reductive-amination capacity.

• Starting material. 4-Fluoroaniline is used as the aromatic amine starting point.
• N-alkylation. Reductive amination with acetone, or direct alkylation with an isopropyl halide, introduces the isopropyl group onto the amine nitrogen.
• Selectivity control. Reaction conditions are controlled to favour the mono-isopropylated secondary amine over the tertiary (di-isopropyl) by-product.
• Purification. The crude product is purified by distillation to the target purity, typically 97–98% or better.
• Quality release and packing. Assay and appearance are confirmed against specification, and the liquid is packed under protective, light- and moisture-controlled conditions.

Typical Commercial Specification

Figures below are representative of commercial-grade 4-fluoro-N-isopropylaniline. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.

Physical & Chemical Properties

Behaviour in the process

4-Fluoro-N-isopropylaniline's reactivity pattern is what pharma and agro intermediate producers are buying:

• Secondary amine reactivity. The N–H undergoes standard acylation, sulfonylation and further alkylation chemistry common to secondary aromatic amines.
• Diazotisation limitations. As a secondary amine, it does not diazotise the way a primary aniline does; routes needing diazotisation chemistry should use a primary fluoroaniline instead.
• Base reactivity. As a weak amine base, it readily forms salts with acids.
• Light and air sensitivity. Recommended storage in amber, sealed containers reflects a general sensitivity to light and air common to aromatic amines.

4-Fluoro-N-isopropylaniline and Related Fluoroanilines

4-Fluoro-N-isopropylaniline is one of several fluorinated aniline building blocks, and the choice between them depends on the substitution pattern the target synthesis needs.

Stated plainly: 4-Fluoro-N-isopropylaniline saves a synthesis step wherever the target molecule's nitrogen substituent is specifically isopropyl; where a primary amine or a different N-substituent is needed, a different fluoroaniline is the right choice.

Industries We Supply 4-Fluoro-N-isopropylaniline To

The same fluoroaniline building block feeds a pharmaceutical intermediate plant, an agrochemical producer, and a fine-chemical custom-synthesis house. What changes is the downstream functionalisation chemistry and the documentation each requires.

Where 4-Fluoro-N-isopropylaniline is Used

4-Fluoro-N-isopropylaniline is bought for several distinct downstream chemistries. These are the applications our customers use it for.

In pharmaceutical and agrochemical synthesis

4-Fluoro-N-isopropylaniline's secondary amine nitrogen is carried through into the target active ingredient via standard acylation, sulfonylation or further functionalisation chemistry, saving a separate N-isopropylation step downstream. Related-substances purity matters because unreacted 4-fluoroaniline or the tertiary by-product can carry through to the final product.

In research and custom synthesis

In research and screening-compound work, the molecule offers a ready-made N-isopropylfluoroaniline fragment, saving a synthetic step when building related analogues for structure-activity studies.

Quality Control & Testing

Every lot is released against a batch-specific Certificate of Analysis, with related-substances content reported alongside the main assay because both affect downstream reaction selectivity and yield.

• 4-Fluoro-N-isopropylaniline content — by GC assay, the primary grade measure.
• Related substances — unreacted 4-fluoroaniline and the di-isopropyl by-product, reported because both affect downstream reaction selectivity.
• Appearance and colour — reported as a general handling and storage-quality indicator.
• Moisture content — measured because moisture can interfere with sensitive downstream chemistry.

Common Process Problems & Likely Causes

When this amine causes trouble, it is usually related-substances carryover or storage-related discolouration. This table is the shortcut our technical desk works through before anyone opens a complaint file.

Packaging, Storage & Shipping

• Standard packing. Amber-glass bottles or lined drums, typically 1 – 200 kg net, with larger bulk formats on contract supply.
• Light and air protection. Keep sealed in an amber or opaque container, protected from light and air, which can cause gradual discolouration.
• Temperature control. Store below 10 °C in a cool, dry location away from heat sources.
• Material compatibility. Avoid contact with strong oxidisers and strong acids.
• Shelf life. Best used within a reasonable period of manufacture when stored correctly; retest on long storage.
• Transport classification. Public sources do not show a universally assigned UN number for this specific compound. Confirm the correct classification against your own supplier's current SDS before shipping, rather than assuming a generic aniline-class rating.

Hazards & Safe Handling

As a fluorinated secondary aromatic amine, 4-Fluoro-N-isopropylaniline should be handled under the general precautions used for aromatic amines: avoiding skin and eye contact, avoiding inhalation of vapour, and working in a ventilated area. Published, compound-specific GHS classification data is limited for this material, so the current SDS — rather than general assumptions — should govern your handling procedures and PPE selection.

• Skin and eye contact. Chemical-resistant gloves and goggles are standard practice for aromatic amines; rinse thoroughly with water on contact.
• Inhalation. Use adequate ventilation; work in a fume hood for laboratory-scale handling.
• PPE. Chemical-resistant gloves and safety goggles as a baseline; follow the specific guidance in the current SDS for respiratory protection.
• Documentation first. Because published hazard data for this exact compound is limited, review the SDS we supply with your order before finalising your own risk assessment and PPE selection.

Regulatory & Compliance Notes

4-Fluoro-N-isopropylaniline is a specialty amine intermediate. Because published regulatory and transport classification data is limited for this specific compound, and obligations differ by territory and use, the notes below are orientation rather than legal advice — confirm your own position with your regulatory adviser and against the current SDS.

• GHS classification. Confirm the applicable classification against the current SDS rather than assuming a generic aromatic-amine rating.
• Chemical inventories. Confirm registration status on the inventories relevant to your destination market before first import.
• Dangerous goods transport. Confirm whether your specific shipment requires dangerous-goods documentation based on the current SDS; do not assume a UN number without confirming it with your supplier or carrier.
• HS code. Commonly declared under the amine derivatives heading; confirm the exact tariff line with your customs broker for your jurisdiction.
• Quality agreements. Pharma and agrochemical producers commonly expect documented purity, related-substances control and change control. Tell us what your agreement requires.

We Supply 4-Fluoro-N-isopropylaniline Worldwide

Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship 4-Fluoro-N-isopropylaniline from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.

• Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
• Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
• Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
• Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.
• Supply continuity. Because we are independent of any one producer, a plant turnaround or a shipping disruption at one source does not have to become your stock-out.

Buying 4-Fluoro-N-isopropylaniline from Chelora

We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the purity grade your application needs, the packing format, and the quantity you are buying.

• Documentation on every lot. Batch-specific COA with assay and related substances, plus the current SDS.
• Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
• Quantities. Trial quantities through to larger bulk shipments on contract supply.
• Inspection. Independent third-party inspection available at loading when the contract requires it.
• Related fluoroanilines. Other fluoroaniline and fluoronitrobenzene intermediates alongside this product from one supplier.

How ordering works

• Send the enquiry. Purity grade, quantity, destination port and the Incoterm you buy on. If you have a spec sheet, attach it — it saves a round trip.
• We quote. Price, lead time, packing format and a sample COA, normally within one working day.
• Qualify the supply. For first orders or pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
• Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
• Allocation and QC. Material allocated and released against a batch-specific COA, with an independent inspection where the contract calls for it.
• Ship and document. Packed, labelled and loaded with documentation matched to your confirmed transport classification, and tracked through to arrival.

Related Fluoroaromatic Intermediates

Buyers of 4-fluoro-N-isopropylaniline often source other fluorinated and aromatic amine intermediates alongside it. Consolidating them cuts freight cost and gives you a single point of contact for documentation.