2,3,4-Trifluoroaniline
A high-purity trifluorinated aromatic amine supplied for fluoroquinolone and pharmaceutical intermediate synthesis, agrochemical actives, and advanced materials.
What is 2,3,4-Trifluoroaniline?
2,3,4-Trifluoroaniline — 234TFA — is a colourless to amber liquid carrying three fluorines on consecutive ring carbons next to an amino group. It is obtained by reducing 2,3,4-trifluoronitrobenzene.
Three fluorines on one ring produce a strongly electron-poor, weakly basic amine that resists metabolic oxidation almost completely. That combination of stability and electronic character is what medicinal chemists are buying, particularly in the fluoroquinolone antibacterial families.
At Chelora Chemicals, 234TFA is distilled to high assay and low colour, with isomer content and moisture controlled to a level suitable for regulated pharmaceutical intermediate supply.
- Appearance
- Colourless to amber liquid
- Odour
- Characteristic amine odour
- Solubility
- Slightly soluble in water; soluble in organic solvents
- Function
- Chemical intermediate
- Grade
- High purity / pharma intermediate
Formula diagram
Aniline ring with three fluorines on consecutive carbons
- Molecular formulaC6H4F3N
- Molecular weight147.10 g/mol
- IUPAC name2,3,4-Trifluoroaniline
- Functional groupsPrimary aromatic amine, aryl fluoride
- CAS number3862-73-5
Technical product information
Standard specification for Chelora Chemicals' high-purity pharma-intermediate grade 2,3,4-Trifluoroaniline. Custom-grade and bulk specifications are available on request.
| Chemical name | 2,3,4-Trifluoroaniline |
|---|---|
| Synonyms | 234TFA, 2,3,4-Trifluorobenzenamine, 2,3,4-TFA |
| CAS number | 3862-73-5 |
| Molecular formula | C6H4F3N |
| Molecular weight | 147.10 g/mol |
| Assay (GC purity) | ≥ 99.0% |
| Appearance | Clear, colourless to amber liquid |
| Density (20°C) | 1.32–1.38 g/cm³ |
| Boiling point | approx. 172°C |
| Flash point | > 65°C (closed cup) |
| Isomer content | ≤ 0.5% |
| Water content | ≤ 0.2% |
| Packaging | 25 kg & 200 kg drums |
| Shelf life | 12 months in sealed original packaging |
Applications of 2,3,4-Trifluoroaniline
Fluoroquinolone intermediates
Used in the synthesis of quinolone antibacterial cores built on a trifluorinated ring.
Pharmaceutical intermediates
Supplies a highly fluorinated aniline fragment for API and development compound synthesis.
Amide & heterocycle chemistry
Acylated or cyclised to build fluorinated amides and nitrogen heterocycles.
Agrochemical intermediates
Introduces a trifluorinated aromatic fragment into crop-protection actives.
Liquid crystal & materials
Feeds fluorinated intermediates for specialty electronic and display materials.
Custom synthesis
Supplied as a contract manufacturing and development building block.
Why choose Chelora Chemicals
Every batch of 2,3,4-Trifluoroaniline is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
GC assay controlled at ≥99% with isomer content, colour, and water verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 25 kg drums to 200 kg drums, with samples for development and qualification work.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly sealed original containers under nitrogen where possible.
- 02Keep cool, dry, and out of direct sunlight; the product darkens on air and light exposure.
- 03Keep away from heat, sparks, and open flame.
- 04Segregate from strong oxidising agents, acids, and acid chlorides.
- 05Use compatible containers: glass, stainless steel, or lined steel.
- 06Re-seal and re-blanket containers immediately after each withdrawal.
Handling precautions
234TFA is a toxic aromatic amine, harmful in contact with skin, by inhalation, and if swallowed. It is for industrial use by trained personnel only.
Aromatic amines are absorbed through intact skin and can affect the blood by forming methaemoglobin. Chemical-resistant gloves, coveralls, and eye protection are required.
The product is combustible. Keep away from ignition sources and earth equipment during transfer.
Use local exhaust ventilation for decanting, charging, and heated operations, and avoid breathing vapour or mist.
Refer to the full Safety Data Sheet for exposure limits, spill containment, disposal, and first-aid measures before use.
Frequently asked questions
What is 2,3,4-Trifluoroaniline used for?
It is a pharmaceutical intermediate, used in fluoroquinolone antibacterial synthesis and other routes needing a heavily fluorinated aniline. It also serves agrochemical and specialty material chemistry.
How is 234TFA manufactured?
By reducing 2,3,4-trifluoronitrobenzene, usually by catalytic hydrogenation. The nitro compound is itself made by halex fluorination of the trichloro analogue, so the whole chain runs through three products in this range.
What do three fluorines do to the amine?
They withdraw electron density strongly, making the amine markedly less basic and less nucleophilic than aniline. Acylation and condensation therefore need more forcing conditions or more reactive reagents.
Why is heavy fluorination valuable in drug molecules?
Fluorine blocks the ring positions where metabolic oxidation would normally occur, raises lipophilicity, and shifts electron distribution. Together those effects can substantially improve a compound's stability and activity.
Are the fluorines reactive?
Not once the nitro group has been reduced. Without that activation the carbon–fluorine bonds are very stable, so the amine is the reactive handle and the fluorines remain in the final molecule.
Why does the liquid darken during storage?
Aromatic amines oxidise on contact with air and light. Nitrogen blanketing and cool, dark storage slow this considerably, and moderate colour development does not usually affect assay.
Is it soluble in water?
Only slightly. It is readily soluble in alcohols, ethers, esters, and aromatic hydrocarbons, so reactions are run in organic media.
What purity do you supply?
Standard grade is supplied at a minimum GC assay of 99% with isomer content at or below 0.5% and water at or below 0.2%. Tighter specifications can be manufactured for regulated pharmaceutical intermediate supply.
What packaging sizes are available?
25 kg and 200 kg drums under nitrogen, with laboratory and pilot samples available for development and qualification work.
Can you supply to a regulated pharmaceutical specification?
Yes. Isomer limits, residual solvent, metals, and colour can be tightened to a customer specification sheet, with the supporting analytical documentation required for qualification.
Is 234TFA hazardous?
Yes. It is toxic, skin-absorbable, combustible, and hazardous to aquatic life. Engineering controls, PPE, and the Safety Data Sheet should be reviewed before handling.
Do you provide a Certificate of Analysis?
Yes. Every batch ships with a Certificate of Analysis and Safety Data Sheet covering GC assay, isomer content, density, water content, colour, and appearance.