2,3,4-Trifluoroaniline 2,3,4-TFA · CAS 3862-73-5
Chelora Chemicals is a supplier of 2,3,4-Trifluoroaniline, the reduced-amine counterpart of 2,3,4-trifluoronitrobenzene, used as a building block in fluoroquinolone antibiotic and other pharmaceutical intermediate synthesis requiring the adjacent 2,3,4-trifluoro substitution pattern on an aniline nitrogen. Every consignment leaves with a batch-specific COA and the current SDS.
Also known as: 2,3,4-TFA
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Price, lead time and a sample COA for 2,3,4-Trifluoroaniline, usually within one working day. We ship worldwide.
Request a Quote Email the DeskDocumentation
- Batch-specific COA (assay, isomer purity, water content)
- Safety Data Sheet (SDS)
- Dangerous-goods transport documents, confirmed to your SDS
- Third-party inspection on request
- Certificate of origin
What is 2,3,4-Trifluoroaniline?
2,3,4-Trifluoroaniline is a benzene ring carrying three adjacent fluorine atoms and a primary amine group, formula C₆H₄F₃N. It is supplied as a clear to pale liquid or low-melting solid, with a melting point reported around 14 – 15 °C — meaning it can appear as either a liquid or a soft solid depending on ambient temperature.
It is the reduced-amine form of 2,3,4-trifluoronitrobenzene, obtained by catalytic or chemical reduction of the nitro group. The same adjacent 2,3,4-trifluoro substitution pattern that makes the nitrobenzene precursor valuable for fluoroquinolone antibiotic synthesis carries directly through to this aniline, which is used where the free amine, rather than the nitro group, is the reactive handle the synthesis needs.
Commercially it is produced by reducing 2,3,4-trifluoronitrobenzene, typically by catalytic hydrogenation, with the reduction step controlled to avoid over-reduction or dehalogenation side reactions.
Handling follows standard precautions for a fluorinated aniline — chemical-resistant gloves and eye protection, adequate ventilation, and storage away from incompatible materials such as strong oxidisers.
Why 2,3,4-Trifluoroaniline specifically
- The amine-functional form of the fluoroquinolone trifluoro pattern. Carries the same 2,3,4-trifluoro arrangement as the nitrobenzene precursor, but with a reactive amine instead of a nitro group.
- Pharma intermediate. A building block for fluoroquinolone antibiotic and other pharmaceutical synthesis routes that need the free amine.
- Avoids an extra reduction step. Buying the aniline directly, rather than the nitrobenzene, saves a reduction step for routes that need the amine from the outset.
- Distinct from partially fluorinated anilines. The triple-fluorine pattern gives electronic properties that mono- or difluoroanilines do not reproduce.
How 2,3,4-Trifluoroaniline is Manufactured
2,3,4-Trifluoroaniline is produced by reducing the nitro group of 2,3,4-trifluoronitrobenzene, most commonly by catalytic hydrogenation.
- Nitro reduction. 2,3,4-Trifluoronitrobenzene is reduced, typically by catalytic hydrogenation under controlled conditions to avoid dehalogenation side reactions.
- Workup. The crude aniline is separated from catalyst and by-products.
- Purification. The product is purified by distillation to the target assay specification.
- Quality release and packing. Assay, isomer purity and water content are confirmed against specification before the batch is packed and released, typically under nitrogen to limit oxidation.
Typical Commercial Specification
Figures below are representative of commercial-grade 2,3,4-trifluoroaniline. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.
| Parameter | Typical Value |
|---|---|
| Appearance | Clear to pale yellow liquid or low-melting solid |
| 2,3,4-Trifluoroaniline content | 98% min by GC assay |
| Isomer purity | Other trifluoroaniline isomers, trace levels to grade |
| Water content | To grade, typically 0.2% max |
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical formula | C₆H₄F₃N |
| Molecular weight | 147.10 g/mol |
| Appearance | Clear to pale liquid / low-melting solid |
| Melting point | About 14 – 15 °C |
| Boiling point (reduced pressure) | About 92 °C at 48 mmHg |
| Atmospheric boiling point | Confirm against your current SDS* |
| Density | About 1.393 g/mL at 25 °C |
| Flash point | About 68 °C (155 °F) |
| Incompatibilities | Strong oxidisers |
Behaviour in the process
2,3,4-Trifluoroaniline's reactivity pattern is what pharma intermediate producers are buying:
- Amine reactivity. The free amine is available for acylation, diazotisation or cyclisation chemistry building the quinolone ring system without a separate reduction step.
- Oxidative sensitivity. Like many anilines, it darkens on prolonged exposure to air and light; store accordingly.
- Thermal stability. Stable under normal storage conditions away from strong oxidisers.
2,3,4-Trifluoroaniline and Related Fluoroanilines
Choosing between fluoroaniline grades comes down to how many fluorines, and in what pattern, the target synthesis needs, and whether the amine or the nitro precursor is the better starting point.
| Material | Substitution | When it is the right choice |
|---|---|---|
| 2,3,4-Trifluoroaniline | 2,3,4-triF, 1-NH₂ | Where the free amine, not the nitro precursor, is needed directly |
| 2,3,4-Trifluoronitrobenzene | 2,3,4-triF, 1-NO₂ | Where the nitro group's own reactivity, or in-process reduction, fits the route better |
| 2,6-Difluoroaniline | 2,6-diF, 1-NH₂ | Routes needing two fluorines in a symmetric pattern rather than three adjacent ones |
| ortho-Fluoroaniline | 2-F, 1-NH₂ | Routes needing only a single fluorine on the aniline |
Stated plainly: if your route needs the free amine with the adjacent 2,3,4-trifluoro pattern already installed, buying this aniline directly saves a reduction step compared with ordering the nitrobenzene precursor.
Industries We Supply 2,3,4-Trifluoroaniline To
The same trifluoroaniline feeds pharmaceutical API manufacturers and custom-synthesis houses. What changes is the downstream chemistry and the documentation each requires.
Where 2,3,4-Trifluoroaniline is Used
In fluoroquinolone synthesis
2,3,4-Trifluoroaniline's free amine is a direct entry point into quinolone-ring-forming chemistry, avoiding the separate nitro-reduction step a route would otherwise need if it started from the nitrobenzene precursor. This is the core value proposition for producers who have already settled on this amine as their starting material.
Need a specific purity or isomer grade?
Tell us the purity and isomer-purity grade you need, your downstream chemistry, the packing format you can receive and the annual quantity. We will come back with a price, a lead time and a sample COA.
Quality Control & Testing
Every lot is released against a batch-specific Certificate of Analysis, with isomer purity reported alongside the main assay because carryover of other trifluoroaniline isomers affects downstream pharma reaction selectivity.
- 2,3,4-Trifluoroaniline content — by GC assay, the primary grade measure.
- Isomer purity — other trifluoroaniline isomer carryover, reported because it affects downstream chemistry.
- Water content — measured because moisture can affect downstream reaction yield.
- Colour/oxidation check — anilines darken on storage; colour is a useful freshness indicator ahead of use.
Common Process Problems & Likely Causes
| Symptom | Likely cause | What to check |
|---|---|---|
| Off-target reaction product | Other trifluoroaniline isomer carryover | Isomer purity figure on the COA |
| Darkened material on receipt | Oxidation during storage or transit | Colour and age of the lot; storage conditions |
| Low cyclisation yield | Isomer carryover or oxidation by-products | Isomer breakdown and colour on the COA |
Packaging, Storage & Shipping
- Standard packing. Drums or jerricans, typically 25 – 200 kg net, with larger bulk formats on contract supply.
- Oxidation protection. Store under nitrogen where possible and keep containers tightly sealed to limit darkening.
- Temperature control. Store in a cool, dry, well-ventilated area away from direct sun, heat and ignition sources.
- Material compatibility. Avoid contact with strong oxidisers.
- Transport classification. Confirm the UN number and transport class against your own current SDS before shipping — published sources for this specific compound did not report a confirmed UN number at drafting time.
Hazards & Safe Handling
2,3,4-Trifluoroaniline is a fluorinated aniline and should be handled with the standard precautions that apply to this class of compound. Refer to the current SDS for your grade for the complete hazard classification.
- Skin and eye contact. Chemical-resistant gloves and goggles are standard practice for fluorinated anilines; rinse thoroughly with water on contact.
- Inhalation. Use adequate ventilation when handling, given the material's volatility.
- PPE. Chemical-resistant gloves, safety goggles and, where vapour exposure is a concern, a suitable respirator.
- Fire. Keep away from ignition sources given the reported flash point; store accordingly.
Regulatory & Compliance Notes
2,3,4-Trifluoroaniline is a registered pharma-intermediate fluoroaromatic. Because obligations differ by territory and use, and because confirmed UN transport data for this compound was not found in public sources at drafting time, the notes below are orientation rather than legal advice.
- GHS classification. Refer to your supplier's current SDS for the full classification applicable to your grade.
- REACH and chemical inventories. Registered under EU REACH and listed on major chemical inventories.
- Dangerous goods transport. Confirm the UN number, transport class and packing group with your logistics/EHS team against your current SDS before shipping.
- HS code. Commonly declared under the aromatic amine derivatives heading; confirm the exact tariff line with your customs broker for your jurisdiction.
We Supply 2,3,4-Trifluoroaniline Worldwide
Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship 2,3,4-Trifluoroaniline from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.
- Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
- Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
- Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
- Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.
Buying 2,3,4-Trifluoroaniline from Chelora
We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the purity and isomer-purity grade your application needs, the packing format, and the quantity you are buying — and confirming transport classification with you before the first shipment.
- Documentation on every lot. Batch-specific COA with assay and isomer breakdown, plus the current SDS.
- Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
- Quantities. Trial quantities through to larger bulk shipments on contract supply.
- Inspection. Independent third-party inspection available at loading when the contract requires it.
- Related fluoroaromatics. 2,3,4-Trifluoronitrobenzene (the nitro precursor), potassium fluoride, and other fluoroanilines alongside this product from one supplier.
How ordering works
- Send the enquiry. Purity, isomer-purity grade, quantity, destination port and the Incoterm you buy on.
- We quote. Price, lead time, packing format and a sample COA, normally within one working day.
- Qualify the supply. For first orders or pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
- Confirm transport classification. We work with you and your logistics team to confirm the UN number and transport class for your lane.
- Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
- Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.
2,3,4-Trifluoroaniline — Common Questions
The questions our technical desk is asked most often about 2,3,4-Trifluoroaniline. If yours isn't here, call or email and you will reach someone who knows the chemistry.
What is the CAS number of 2,3,4-Trifluoroaniline?
The CAS number for 2,3,4-Trifluoroaniline is 3862-73-5. Its molecular formula is C₆H₄F₃N with a molecular weight of 147.10 g/mol.
What is 2,3,4-Trifluoroaniline used for?
It is used as a building block in fluoroquinolone antibiotic and other pharmaceutical intermediate synthesis requiring the adjacent 2,3,4-trifluoro pattern on an aniline nitrogen.
Do you supply 2,3,4-Trifluoroaniline worldwide?
Yes. Chelora Chemicals supplies and exports 2,3,4-Trifluoroaniline worldwide — across Asia Pacific, Europe, the Middle East, Africa and the Americas, as well as throughout India. Every consignment carries the COA and SDS.
How is 2,3,4-Trifluoroaniline manufactured?
By reducing the nitro group of 2,3,4-trifluoronitrobenzene, typically by catalytic hydrogenation, then purifying the resulting aniline by distillation.
Is 2,3,4-Trifluoroaniline hazardous?
It is a fluorinated aniline handled with standard precautions for this class of compound. Refer to the current SDS for your grade for the complete hazard classification.
What is the UN number and transport classification?
A reliably confirmed, compound-specific UN number was not found in public sources at drafting time. Confirm transport classification against your own current SDS before relying on it for shipping documentation.
What are the melting point, boiling point and density?
Typical figures are a melting point around 14 – 15 °C, a boiling point of about 92 °C at reduced pressure (48 mmHg, not atmospheric), and a density around 1.393 g/mL at 25 °C. Confirm against your own supplier's COA for batch-specific figures and atmospheric boiling point.
How does it differ from 2,3,4-trifluoronitrobenzene?
They share the same 2,3,4-trifluoro substitution pattern on the ring, but this aniline carries a reactive amine where the nitrobenzene carries a nitro group — buying the aniline directly saves a reduction step for routes that need the free amine.
How should 2,3,4-Trifluoroaniline be stored?
In sealed containers, ideally under nitrogen, cool, dry and away from direct sun, heat, ignition sources and strong oxidisers. Like most anilines it can darken on prolonged exposure to air and light.
What purity grades do you offer?
Standard commercial grade is 98% minimum by GC assay, with isomer purity and water content reported on the COA.
What packing sizes and order quantities are available?
Drums or jerricans, typically 25–200 kg net, with larger bulk formats available on contract supply. Orders run from trial quantities up to repeat bulk loads.
Ready to source 2,3,4-Trifluoroaniline?
Send us your purity requirement and annual volume. You will get a price, a realistic lead time and a sample COA from someone who understands what the material has to do in your process — delivered anywhere in the world.