3,4,5-Trifluoro Bromo Benzene
A high-purity polyfluorinated aryl bromide supplied for liquid crystal manufacture, cross-coupling chemistry, and advanced pharmaceutical and electronic material synthesis.
What is 3,4,5-Trifluoro Bromo Benzene?
3,4,5-Trifluoro Bromo Benzene — 1-bromo-3,4,5-trifluorobenzene — is a colourless to pale yellow liquid carrying three fluorine atoms across the 3, 4, and 5 positions and a bromine at position 1.
The bromine is the reactive site. It converts cleanly to a Grignard reagent, an organolithium, or a boronic acid, which then enters Suzuki, Negishi, and related cross-coupling reactions. The trifluorinated ring that comes along with it carries a strong dipole and high thermal stability — exactly the properties display-grade liquid crystal molecules are built around.
At Chelora Chemicals, 345TFBrB is distilled to high assay with isomer content and moisture tightly controlled, since trace impurities carry straight through coupling chemistry into the finished electronic or pharmaceutical material.
- Appearance
- Colourless to pale yellow liquid
- Odour
- Faint aromatic
- Solubility
- Insoluble in water; soluble in most organic solvents
- Function
- Chemical intermediate / coupling partner
- Grade
- High purity / electronic
Formula diagram
Benzene ring with three fluorines and one bromine substituent
- Molecular formulaC6H2BrF3
- Molecular weight210.98 g/mol
- IUPAC name1-Bromo-3,4,5-trifluorobenzene
- Functional groupsAryl bromide, aryl fluoride
- CAS number138526-69-9
Technical product information
Standard specification for Chelora Chemicals' high-purity electronic and pharma-intermediate grade 3,4,5-Trifluoro Bromo Benzene. Custom-grade and bulk specifications are available on request.
| Chemical name | 3,4,5-Trifluoro Bromo Benzene |
|---|---|
| Synonyms | 345TFBrB, 1-Bromo-3,4,5-trifluorobenzene, 3,4,5-Trifluorobromobenzene |
| CAS number | 138526-69-9 |
| Molecular formula | C6H2BrF3 |
| Molecular weight | 210.98 g/mol |
| Assay (GC purity) | ≥ 99.0% |
| Appearance | Clear, colourless to pale yellow liquid |
| Density (20°C) | 1.78–1.80 g/cm³ |
| Boiling point | 154–156°C |
| Flash point | ≈ 48°C (closed cup) |
| Refractive index (20°C) | 1.478–1.484 |
| Water content | ≤ 0.05% |
| Packaging | 25 kg & 200 kg drums |
| Shelf life | 24 months in sealed original packaging |
Applications of 3,4,5-Trifluoro Bromo Benzene
Liquid crystal materials
A core building block for fluorinated LC molecules used in display manufacture, where ring polarity and thermal stability are critical.
Suzuki & cross-coupling
Converted to boronic acids and esters, or used directly as the aryl halide partner in palladium-catalysed coupling.
Grignard chemistry
Forms the corresponding aryl magnesium reagent for addition and substitution routes.
Pharmaceutical intermediates
Introduces a trifluorinated aromatic fragment into API scaffolds and development compounds.
Agrochemical synthesis
Used to build polyfluorinated cores in modern crop-protection actives.
Electronic materials
Applied in OLED and specialty electronic material synthesis where high purity is essential.
Why choose Chelora Chemicals
Every batch of 3,4,5-Trifluoro Bromo Benzene is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
GC assay controlled at ≥99% with isomer profile and low moisture verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 25 kg drums to 200 kg drums, with laboratory samples for development work.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly sealed original containers in a cool, dry, well-ventilated store.
- 02Keep below 25°C and away from heat, sparks, and open flame — the flash point is low.
- 03Protect from moisture; water content matters for downstream Grignard and organolithium chemistry.
- 04Segregate from strong oxidising agents, strong bases, and active metals.
- 05Use compatible containers: glass, stainless steel, or lined steel. Keep under nitrogen where practical.
- 06Earth and bond all containers and lines during transfer to control static.
Handling precautions
The product is a flammable liquid with a flash point near 48°C. Eliminate ignition sources and use explosion-protected equipment in the handling area.
It causes skin and eye irritation and may cause respiratory irritation. Use chemical-resistant gloves, eye protection, and adequate ventilation.
Downstream Grignard and organolithium chemistry using this material carries its own significant hazards, including exotherm and pyrophoric reagent risk, and requires a separate process risk assessment.
Avoid release to the environment and contain all spills with inert absorbent for licensed disposal.
Refer to the full Safety Data Sheet for exposure limits, fire-fighting measures, spill response, and first-aid information before use.
Frequently asked questions
What is 3,4,5-Trifluoro Bromo Benzene used for?
Mainly as a coupling building block. It is converted into boronic acids, Grignard reagents, or organolithiums and coupled into liquid crystal molecules, pharmaceutical scaffolds, agrochemicals, and electronic materials.
Why is the bromine the reactive site rather than the fluorine?
The carbon-bromine bond is far weaker and more polarisable than carbon-fluorine, so it undergoes oxidative addition to palladium, metal-halogen exchange, and Grignard formation readily. The three fluorines stay put and become a permanent part of the final molecule.
Why does the trifluoro pattern matter for liquid crystals?
Three fluorines arranged across the 3, 4, and 5 positions give the ring a large dipole moment along the molecular axis and high chemical and thermal stability. Those properties drive the dielectric anisotropy and switching behaviour that display materials depend on.
What purity do you supply?
Standard grade is supplied at a minimum GC assay of 99% with water content at or below 0.05%. Electronic-grade specifications with tighter isomer and metals limits can be manufactured to order.
Why is water content specified so tightly?
Grignard and organolithium formation are destroyed by moisture, and residual water reduces yield and can cause reaction failures at scale. Low moisture is therefore a functional specification, not a cosmetic one.
Is it soluble in water?
No. It is practically insoluble in water and readily soluble in THF, ether, toluene, and most common organic solvents used for coupling chemistry.
What packaging sizes are available?
25 kg and 200 kg drums, with laboratory and pilot samples available for development and qualification work.
How should it be stored?
In sealed original containers below 25°C in a cool, dry, ventilated store away from ignition sources, moisture, and oxidising agents. Nitrogen blanketing is recommended for opened containers.
Is the product flammable?
Yes. With a flash point near 48°C it is classified as a flammable liquid. Static control, bonding and earthing, and explosion-protected equipment are required during transfer.
Can you supply against a custom specification?
Yes. Isomer limits, metals content, colour, and moisture can all be tightened to a customer specification sheet for electronic or pharmaceutical intermediate use.
Do you provide a Certificate of Analysis?
Yes. Every batch is dispatched with a Certificate of Analysis and Safety Data Sheet covering GC assay, refractive index, density, water content, and appearance.