2,6-Difluoroaniline
A high-purity doubly fluorinated aromatic amine supplied for pharmaceutical intermediate synthesis, agrochemical actives, and fine chemical manufacture.
What is 2,6-Difluoroaniline?
2,6-Difluoroaniline — 26DFA — is a colourless to pale amber liquid with fluorine atoms on both carbons flanking the amino group.
Two ortho fluorines pull hard on the nitrogen's electron density, making this one of the least basic simple anilines available. The amine is correspondingly harder to acylate, but the resulting amides carry a fluorinated, metabolically robust ring that is valuable in both drug and crop-protection design.
At Chelora Chemicals, 26DFA is distilled to high assay and low colour, with isomer content and moisture controlled to a level suitable for pharmaceutical intermediate use.
- Appearance
- Colourless to pale amber liquid
- Odour
- Characteristic amine odour
- Solubility
- Slightly soluble in water; soluble in organic solvents
- Function
- Chemical intermediate
- Grade
- High purity / pharma intermediate
Formula diagram
Aniline ring with fluorine on both positions flanking the amine
- Molecular formulaC6H5F2N
- Molecular weight129.11 g/mol
- IUPAC name2,6-Difluoroaniline
- Functional groupsPrimary aromatic amine, aryl fluoride
- CAS number5509-65-9
Technical product information
Standard specification for Chelora Chemicals' high-purity intermediate 2,6-Difluoroaniline. Custom-grade and bulk specifications are available on request.
| Chemical name | 2,6-Difluoroaniline |
|---|---|
| Synonyms | 26DFA, 2,6-DFA, 2,6-Difluorobenzenamine |
| CAS number | 5509-65-9 |
| Molecular formula | C6H5F2N |
| Molecular weight | 129.11 g/mol |
| Assay (GC purity) | ≥ 99.0% |
| Appearance | Clear, colourless to pale amber liquid |
| Density (20°C) | 1.22–1.26 g/cm³ |
| Boiling point | 168–172°C |
| Flash point | ≈ 65°C (closed cup) |
| Isomer content | ≤ 0.5% |
| Water content | ≤ 0.2% |
| Packaging | 25 kg & 200 kg drums |
| Shelf life | 12 months in sealed original packaging |
Applications of 2,6-Difluoroaniline
Pharmaceutical intermediates
Supplies a doubly fluorinated aniline core for API and development compound synthesis.
Agrochemical intermediates
Used to build fluorinated fragments in insecticide and fungicide actives.
Amide & urea chemistry
Acylated or reacted with isocyanates to give fluorinated amides and ureas.
Heterocyclic synthesis
Condensed into fluorinated nitrogen heterocycles for medicinal chemistry.
Liquid crystal materials
Feeds fluorinated intermediates for display-grade material manufacture.
Custom synthesis
Supplied as a research and contract manufacturing building block.
Why choose Chelora Chemicals
Every batch of 2,6-Difluoroaniline is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
GC assay controlled at ≥99% with isomer content, colour, and water verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 25 kg drums to 200 kg drums, with laboratory samples for development work.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly sealed original containers under nitrogen where possible.
- 02Keep cool, dry, and out of direct sunlight; the product darkens on air and light exposure.
- 03Keep away from heat, sparks, and open flame — the flash point is around 65°C.
- 04Segregate from strong oxidising agents, acids, and acid chlorides.
- 05Use compatible containers: glass, stainless steel, or lined steel.
- 06Re-seal and re-blanket containers immediately after each withdrawal.
Handling precautions
26DFA is a toxic aromatic amine, harmful in contact with skin, by inhalation, and if swallowed. It is for industrial use by trained personnel only.
Aromatic amines are absorbed through intact skin and can affect the blood by forming methaemoglobin. Chemical-resistant gloves, coveralls, and eye protection are required.
The product is combustible. Keep away from ignition sources and earth equipment during transfer.
Use local exhaust ventilation for decanting, charging, and heated operations, and avoid breathing vapour or mist.
Refer to the full Safety Data Sheet for exposure limits, spill containment, disposal, and first-aid measures before use.
Frequently asked questions
What is 2,6-Difluoroaniline used for?
It is an intermediate for fluorinated pharmaceuticals and agrochemicals, used where a doubly fluorinated aniline fragment is needed in an amide, urea, or heterocyclic structure.
Why are two ortho fluorines useful?
They block both positions next to the nitrogen against metabolic oxidation and unwanted substitution, and they lower the basicity of the amine substantially. The result is a robust fluorinated fragment that survives in the final molecule.
Does the low basicity make it harder to work with?
It does affect conditions. Acylation typically needs a more reactive acylating agent or more forcing conditions than a plain aniline would require, so routes are usually designed around that rather than adapted from unfluorinated chemistry.
Are the fluorines reactive?
Not under ordinary conditions. Without strong activating groups on the ring, the carbon–fluorine bonds are very stable, so the amine is the reactive handle.
How does 26DFA differ from 2,6-dichloroaniline?
Both are doubly ortho-substituted anilines, but fluorine is much smaller than chlorine. The chloro compound is dominated by steric hindrance and twisted amide geometry; the fluoro compound is dominated by electronic effects and metabolic stability.
Why does the liquid darken during storage?
Aromatic amines oxidise on contact with air and light. Nitrogen blanketing and cool, dark storage slow this considerably, and assay is usually unaffected by moderate colour development.
Is it soluble in water?
Only slightly. It is readily soluble in alcohols, ethers, esters, and aromatic hydrocarbons, so reactions are run in organic media.
What purity do you supply?
Standard grade is supplied at a minimum GC assay of 99% with isomer content at or below 0.5% and water at or below 0.2%. Tighter specifications can be manufactured for pharmaceutical intermediate use.
What packaging sizes are available?
25 kg and 200 kg drums under nitrogen, with laboratory and pilot samples available for development work.
Is 26DFA hazardous?
Yes. It is toxic, skin-absorbable, combustible, and hazardous to aquatic life. Engineering controls, PPE, and the Safety Data Sheet should be reviewed before handling.
Do you provide a Certificate of Analysis?
Yes. Every batch ships with a Certificate of Analysis and Safety Data Sheet covering GC assay, isomer content, density, water content, colour, and appearance.