2,6-Difluoroaniline 2,6-DFA · CAS 5509-65-9

What is 2,6-Difluoroaniline?

2,6-Difluoroaniline is a benzene ring carrying two fluorine atoms symmetrically placed on either side of a primary amine group, formula C₆H₅F₂N. Public sources disagree on its exact physical state near room temperature: several commercial listings describe it as a liquid, while at least one calculated-property source gives a melting point around 39 °C. We present it here as a liquid to low-melting solid and flag this discrepancy for confirmation against your own SDS.

Its value as an intermediate comes from the symmetric 2,6-difluoro substitution, which gives a defined electronic effect on the amine while keeping the molecule simpler than the trifluorinated analogues used in some pharma routes. It is used across pharmaceutical and agrochemical synthesis wherever this specific pattern is the structural requirement.

Commercially it is produced by reducing 2,6-difluoronitrobenzene, typically by catalytic hydrogenation, or via other standard routes to a symmetrically difluorinated aniline.

Handling follows standard precautions for a fluorinated aniline — chemical-resistant gloves and eye protection, adequate ventilation, and storage away from incompatible materials such as strong oxidisers. Like most anilines, it darkens with prolonged exposure to air and light.

Why 2,6-Difluoroaniline specifically

• A symmetric difluoro substitution. The 2,6-pattern gives a defined, symmetric electronic effect on the amine that some pharma and agro syntheses are specifically built around.
• Pharma intermediate. A building block for pharmaceutical synthesis routes requiring this specific substitution pattern.
• Agrochemical building block. Used in selected herbicide and pesticide intermediate routes.
• Simpler than trifluorinated analogues. Two fluorines rather than three keeps cost and complexity lower where the route does not need a third fluorine.

How 2,6-Difluoroaniline is Manufactured

2,6-Difluoroaniline is produced by reducing 2,6-difluoronitrobenzene, most commonly by catalytic hydrogenation.

• Nitro reduction. 2,6-Difluoronitrobenzene is reduced, typically by catalytic hydrogenation under controlled conditions.
• Workup. The crude aniline is separated from catalyst and by-products.
• Purification. The product is purified by distillation or crystallisation, depending on its physical state, to the target assay specification.
• Quality release and packing. Assay, colour and water content are confirmed against specification before the batch is packed and released, typically under nitrogen to limit oxidation.

Typical Commercial Specification

Figures below are representative of commercial-grade 2,6-difluoroaniline. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.

Physical & Chemical Properties

Behaviour in the process

2,6-Difluoroaniline's reactivity pattern is what pharma and agro intermediate producers are buying:

• Amine reactivity. The free amine is available for acylation, diazotisation or cyclisation chemistry.
• Oxidative sensitivity. Like many anilines, it darkens on prolonged exposure to air and light; store accordingly.
• Thermal stability. Stable under normal storage conditions away from strong oxidisers.

2,6-Difluoroaniline and Related Fluoroanilines

Choosing between fluoroaniline grades comes down to how many fluorines, and in what pattern, the target synthesis needs.

Stated plainly: a synthesis built around a symmetric 2,6-difluoro pattern on an aniline needs this specific compound — the mono- and trifluorinated analogues have different electronic properties and are not drop-in substitutes.

Industries We Supply 2,6-Difluoroaniline To

The same difluoroaniline feeds pharmaceutical and agrochemical intermediate producers. What changes is the downstream chemistry and the documentation each requires.

Where 2,6-Difluoroaniline is Used

In downstream functionalisation

2,6-Difluoroaniline's free amine is carried through acylation, diazotisation or cyclisation chemistry to build the target pharma or agro intermediate. The symmetric difluoro pattern gives a defined electronic effect that the mono- or trifluorinated analogues do not reproduce — often exactly why a route is designed around this material specifically.

Quality Control & Testing

Every lot is released against a batch-specific Certificate of Analysis, with colour reported alongside the main assay because anilines oxidise on storage and colour is a useful freshness indicator.

• 2,6-Difluoroaniline content — by GC assay, the primary grade measure.
• Colour — reported because oxidation darkens anilines over time.
• Water content — measured because moisture can affect downstream reaction yield.

Common Process Problems & Likely Causes

Packaging, Storage & Shipping

• Standard packing. Drums or jerricans (or fibre drums if supplied as a solid), typically 25 – 200 kg net, with larger bulk formats on contract supply.
• Oxidation protection. Store under nitrogen where possible and keep containers tightly sealed to limit darkening.
• Temperature control. Store in a cool, dry, well-ventilated area away from direct sun, heat and ignition sources.
• Material compatibility. Avoid contact with strong oxidisers.
• Transport classification. Confirm the UN number and transport class against your own current SDS before shipping — published sources for this specific compound did not report a confirmed UN number at drafting time.

Hazards & Safe Handling

2,6-Difluoroaniline is a fluorinated aniline and should be handled with the standard precautions that apply to this class of compound. Refer to the current SDS for your grade for the complete hazard classification.

• Skin and eye contact. Chemical-resistant gloves and goggles are standard practice for fluorinated anilines; rinse thoroughly with water on contact.
• Inhalation. Use adequate ventilation when handling.
• PPE. Chemical-resistant gloves, safety goggles and, where vapour or dust exposure is a concern, a suitable respirator.
• Storage. Keep away from ignition sources and strong oxidisers; confirm flash point against your own current SDS.

Regulatory & Compliance Notes

2,6-Difluoroaniline is a registered specialty fluoroaromatic amine. Because obligations differ by territory and use, and because confirmed physical-state and UN transport data for this compound were not found in public sources at drafting time, the notes below are orientation rather than legal advice.

• GHS classification. Refer to your supplier's current SDS for the full classification applicable to your grade.
• REACH and chemical inventories. Registered under EU REACH and listed on major chemical inventories.
• Dangerous goods transport. Confirm the UN number, transport class and packing group with your logistics/EHS team against your current SDS before shipping.
• HS code. Commonly declared under the aromatic amine derivatives heading; confirm the exact tariff line with your customs broker for your jurisdiction.

We Supply 2,6-Difluoroaniline Worldwide

Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship 2,6-Difluoroaniline from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.

• Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
• Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
• Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
• Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.

Buying 2,6-Difluoroaniline from Chelora

We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the purity grade your application needs, the packing format, and the quantity you are buying — and confirming physical state and transport classification with you before the first shipment.

• Documentation on every lot. Batch-specific COA with assay and colour data, plus the current SDS.
• Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
• Quantities. Trial quantities through to larger bulk shipments on contract supply.
• Inspection. Independent third-party inspection available at loading when the contract requires it.
• Related fluoroanilines. ortho-Fluoroaniline, 2,3,4-trifluoroaniline and 2,6-difluorobenzonitrile alongside this product from one supplier.

How ordering works

• Send the enquiry. Purity grade, quantity, destination port and the Incoterm you buy on.
• We quote. Price, lead time, packing format and a sample COA, normally within one working day.
• Qualify the supply. For first orders or pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
• Confirm physical state and transport classification. We work with you and your logistics team to confirm both for your lane.
• Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
• Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.

Related Fluoroaniline Intermediates