Para Chloro Aniline 4-Chloroaniline · CAS 106-47-8

What is Para Chloro Aniline?

Para Chloro Aniline, formally 4-chloroaniline, is a benzene ring carrying a chlorine atom and an amine group in the para position, formula C₆H₆ClN. At room temperature it is a white to pale yellow solid, melting around 70.5 °C and boiling near 232 °C.

Its value as an intermediate comes from the reactive amine group, which supports diazotisation, acylation and other standard aniline chemistry, letting synthetic chemists build the chlorinated aromatic amine fragment into dyes, pigments, pharmaceuticals and agrochemical active ingredients.

Commercially, it is produced by catalytic hydrogenation of para-chloronitrobenzene, selectively reducing the nitro group to an amine while retaining the chlorine substituent on the ring.

It ships as a toxic solid (Class 6.1) rather than under flammable-liquid classifications — handling follows standard toxic-solid precautions, with particular attention to dust control and skin and eye contact.

Why Para Chloro Aniline specifically

• A reactive aniline building block. The amine group supports diazotisation for azo-dye coupling, acylation, and other standard aromatic-amine chemistry.
• The specific substitution pattern dye and pharma routes need. The para-chloro pattern is distinct from ortho- and meta-chloroaniline, and a route built around it needs this specific isomer.
• Widely used across industries. A common building block in cosmetics, dyes, herbicides and pharmaceutical production.
• Established supply chemistry. Produced via well-understood hydrogenation of para-chloronitrobenzene, giving predictable lead times against standing production capacity.

How Para Chloro Aniline is Manufactured

Para Chloro Aniline is made through a controlled nitration and selective reduction sequence, so supply tracks installed nitroaromatic and hydrogenation capacity rather than a generic aromatics feedstock stream.

• Nitration of chlorobenzene. Chlorobenzene is nitrated under controlled conditions to give para-chloronitrobenzene as the major isomer, separated from the ortho-isomer formed alongside it.
• Selective hydrogenation. Para-chloronitrobenzene is catalytically hydrogenated, reducing the nitro group to an amine while leaving the chlorine on the ring intact.
• Purification. The crude amine is purified by distillation or crystallisation to the target purity, typically 99% or better.
• Quality release. Melting point, GC purity and moisture content are confirmed against specification before the batch is released.
• Finishing and packing. The purified solid is milled or flaked as required and packed under standard toxic-solid handling conditions.

Typical Commercial Specification

Figures below are representative of commercial-grade para chloro aniline. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.

Physical & Chemical Properties

Behaviour in the process

Para Chloro Aniline's reactivity pattern is what synthesis chemists are buying:

• Diazotisation and azo coupling. The amine forms a diazonium salt under standard conditions, a key step toward azo dyes and pigments.
• Acylation and amide formation. The amine readily reacts with acyl chlorides and anhydrides to form amides, an entry point into pharmaceutical and agrochemical intermediates.
• Combustibility. Combustible as a solid; standard ignition-source control applies during processing and milling.
• Dust handling. As a crystalline solid, dust generation during handling should be controlled with appropriate ventilation and PPE.

Para Chloro Aniline and Related Chloroanilines

Para Chloro Aniline is one of several chloroaniline isomers, and the choice between them depends entirely on the substitution pattern the target synthesis needs.

Stated plainly: the choice of chloroaniline isomer is dictated by the target molecule's exact substitution pattern — a route designed around the para-pattern needs this specific isomer, and a different pattern requires a different starting material.

Industries We Supply Para Chloro Aniline To

The same chloroaniline intermediate feeds a dye and pigment plant, an agrochemical producer and a pharmaceutical intermediate manufacturer. What changes is the downstream chemistry and the documentation each requires.

Where Para Chloro Aniline is Used

Para Chloro Aniline is bought almost entirely as a synthesis intermediate. These are the downstream chemistries our customers use it for.

In dye and pharmaceutical synthesis

The amine is diazotised for azo coupling or acylated to build toward active pharmaceutical ingredients. Isomer purity matters because a positional impurity carries through the synthesis and complicates purification of the final product.

In agrochemical and specialty-chemical synthesis

Outside dye and pharma uses, the same chloroaniline fragment contributes to herbicide intermediates and fine-chemical products where the specific substitution pattern is valued.

Quality Control & Testing

Every lot is released against a batch-specific Certificate of Analysis, with isomer purity and moisture content reported alongside the main assay because both affect downstream reaction yield.

• 4-Chloroaniline content — by gas chromatography, the primary grade measure.
• Isomeric chloroanilines — reported because positional isomer carry-over can affect downstream chemistry.
• Moisture content — measured because moisture can interfere with diazotisation and acylation reactions.
• Melting point — a fast purity and identity check.

Common Process Problems & Likely Causes

When this intermediate causes trouble, it is usually isomer carry-over or moisture. This table is the shortcut our technical desk works through before anyone opens a complaint file.

Packaging, Storage & Shipping

• Standard packing. Fibre drums or HDPE bags, typically 25 – 200 kg net, with larger bulk formats on contract supply.
• Moisture exclusion. Keep sealed and dry, particularly where the material will be used directly in diazotisation chemistry.
• Temperature control. Store at room temperature, away from direct sun and heat sources; flash point is about 113 °C.
• Material compatibility. Avoid contact with strong oxidisers and strong acids.
• Shelf life. Stable in sealed, dry containers under normal storage conditions.
• Transport classification. UN 2018, aromatic amine, solid, N.O.S. (or Chloroanilines, solid), Class 6.1, Packing Group III. ADR, IMDG, IATA and DOT requirements apply to packing, labelling and routing.

Hazards & Safe Handling

Para Chloro Aniline is toxic if swallowed or in contact with skin, and is combustible as a solid. Standard toxic-solid precautions and good laboratory and plant practice apply throughout handling.

• Skin and eye contact. Chemical-resistant gloves and goggles are standard practice; remove contaminated clothing and rinse affected areas thoroughly with water.
• Ingestion. Toxic if swallowed; handle with standard laboratory hygiene and avoid dust inhalation.
• Inhalation. Use adequate ventilation and dust control when handling the crystalline solid.
• PPE. Chemical-resistant gloves, safety goggles and, where dust is generated, a suitable respirator.
• Environment. Avoid uncontrolled release to water; follow local effluent and waste-disposal rules.

Regulatory & Compliance Notes

Para Chloro Aniline is a registered specialty aromatic amine shipped as a Class 6.1 toxic solid. Because obligations differ by territory and use, the notes below are orientation rather than legal advice — confirm your own position with your regulatory adviser.

• GHS classification. Typically classified as toxic if swallowed or on skin contact; the SDS carries the full hazard statements for your grade.
• REACH and chemical inventories. Registered under EU REACH and listed on major chemical inventories.
• Dangerous goods transport. UN 2018, aromatic amine, solid, N.O.S., Class 6.1, Packing Group III. ADR, IMDG, IATA and DOT requirements apply to packing, labelling and routing.
• HS code. Commonly declared under the chloroaniline derivatives heading; confirm the exact tariff line with your customs broker for your jurisdiction.
• Quality agreements. Dye, pharma and agrochemical producers commonly expect documented isomer purity and moisture limits and change control. Tell us what your agreement requires.

We Supply Para Chloro Aniline Worldwide

Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship Para Chloro Aniline from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.

• Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
• Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
• Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
• Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.
• Supply continuity. Because we are independent of any one producer, a plant turnaround or a shipping disruption at one source does not have to become your stock-out.

Buying Para Chloro Aniline from Chelora

We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the purity and isomer tolerance your chemistry needs, the packing format, and the quantity you are buying.

• Documentation on every lot. Batch-specific COA with purity, isomer content and moisture, plus the current SDS.
• Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
• Quantities. Trial quantities through to larger bulk shipments on contract supply.
• Inspection. Independent third-party inspection available at loading when the contract requires it.
• Related chloroanilines. Other chlorinated aniline intermediates alongside this product from one supplier.

How ordering works

• Send the enquiry. Purity, quantity, destination port and the Incoterm you buy on. If you have a spec sheet, attach it — it saves a round trip.
• We quote. Price, lead time, packing format and a sample COA, normally within one working day.
• Qualify the supply. For first orders or pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
• Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
• Allocation and QC. Material allocated and released against a batch-specific COA, with an independent inspection where the contract calls for it.
• Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.

Related Chloroaniline & Aromatic Amine Intermediates

Buyers of para chloro aniline often source other chlorinated aniline and aromatic amine intermediates alongside it. Consolidating them cuts freight cost and gives you a single point of contact for documentation.