2,4-Dichlorofluorobenzene 1,5-Dichloro-2-fluorobenzene · CAS 1435-48-9

What is 2,4-Dichlorofluorobenzene?

2,4-Dichlorofluorobenzene is a benzene ring carrying a fluorine and two chlorines in the 2,4-pattern relative to the fluorine, formula C₆H₃Cl₂F. At room temperature it is a clear, colourless to pale yellow liquid.

Its value as an intermediate comes from this specific asymmetric halogen arrangement, which is a key building block in fluoroquinolone antibiotic synthesis (such as ciprofloxacin-class actives) and in selected agrochemical intermediate chemistry, where the positions of the two chlorines relative to the fluorine set up the correct ring-closure and substitution chemistry downstream.

Commercially it is produced through halogenation or halogen-exchange ("halex") chemistry starting from a related chlorinated or fluorinated benzene precursor, with isomer control maintained through the synthesis.

It ships under Class 3 (flammable liquid) rules given its flash point — handling follows standard precautions for a flammable halogenated aromatic liquid.

Why 2,4-Dichlorofluorobenzene specifically

• A fluoroquinolone antibiotic building block. The specific 2,4-dichloro-fluoro pattern sets up the correct substitution chemistry for fluoroquinolone antibiotic intermediate synthesis.
• An asymmetric halogen pattern. Distinct from the symmetric 2,6-dichlorofluorobenzene isomer; routes designed around one are not interchangeable with the other.
• Agrochemical building block. Used in selected crop-protection intermediate syntheses that are designed around this substitution pattern.
• A versatile halex/substitution platform. The chlorines and fluorine each offer distinct reactivity for further functionalisation.

How 2,4-Dichlorofluorobenzene is Manufactured

2,4-Dichlorofluorobenzene is made through halogenation or halogen-exchange ("halex") chemistry starting from a related chlorinated or fluorinated benzene precursor, so supply tracks installed fluoroaromatics capacity rather than a generic chlorobenzene stream.

• Precursor selection. A chlorinated or fluorinated benzene feedstock is chosen to match the target 2,4-substitution pattern.
• Halogenation / halex step. Controlled reaction conditions introduce or exchange the halogens to give the 2,4-dichloro-fluoro pattern.
• Isomer separation. The target isomer is separated from other halogenation products, including the 2,6-isomer, by distillation.
• Purification. The separated fraction is purified to the target purity level, typically 98% or better for pharma-grade material.
• Quality release and packing. Assay and isomer purity are confirmed against specification before the batch is packed and released.

Typical Commercial Specification

Figures below are representative for commercial-grade material. Tell us whether your application is pharmaceutical or agrochemical intermediate chemistry, and we will confirm the exact specification we can supply against.

Physical & Chemical Properties

Behaviour in the process

2,4-Dichlorofluorobenzene's reactivity pattern is what pharma and agro intermediate producers are buying:

• Differential halogen reactivity. The chlorines and the fluorine each offer distinct pathways for further substitution chemistry depending on the target molecule.
• Flammability. Classified as a flammable liquid given its flash point of about 37 °C; keep away from ignition sources during storage and handling.
• Irritant classification. Classified as harmful if swallowed and irritating to skin and eyes — handle with standard PPE.

2,4-Dichlorofluorobenzene and Related Halogenated Benzenes

Choosing between related di- and tri-halogenated benzenes comes down to exactly which halogens, and in which positions, the target synthesis requires.

Stated plainly: fluoroquinolone antibiotic synthesis and other routes built around the asymmetric 2,4-dichloro-fluoro pattern need this specific isomer — the symmetric 2,6-isomer is not a drop-in substitute.

Industries We Supply 2,4-Dichlorofluorobenzene To

The same halogenated-benzene intermediate feeds a pharmaceutical intermediate manufacturer and an agrochemical producer. What changes is the downstream functionalisation chemistry and the documentation each requires.

Where 2,4-Dichlorofluorobenzene is Used

In fluoroquinolone synthesis

2,4-Dichlorofluorobenzene is carried through a sequence of condensation and cyclisation reactions, exploiting the differential reactivity of its two chlorines and the fluorine, to build the characteristic fluoroquinolone core ring system used in ciprofloxacin and related antibacterial actives. The purity and isomer profile of the starting material directly affects the purity of the finished pharmaceutical intermediate, which is why pharma buyers specify tighter isomer limits than other end-uses.

Quality Control & Testing

Every lot is released against a batch-specific Certificate of Analysis, with isomer purity reported alongside the main assay because carryover of the 2,6-isomer or related halogenated byproducts affects downstream reaction selectivity in pharmaceutical synthesis.

• 2,4-Dichlorofluorobenzene content — by GC assay, the primary grade measure.
• Isomer purity — 2,6-isomer and related byproduct carryover, reported because it affects downstream chemistry.
• Moisture content — measured because moisture can affect downstream reaction yield.

Common Process Problems & Likely Causes

Packaging, Storage & Shipping

• Standard packing. Drums or IBCs sized to the order quantity, with bulk tanker options on contract supply.
• Moisture protection. Keep sealed and protected from moisture ingress during storage.
• Fire precautions. Store in a cool, dry, well-ventilated area away from direct sun, heat and ignition sources, given its Class 3 flammable-liquid classification.
• Material compatibility. Avoid contact with strong oxidisers and strong bases.
• Transport classification. UN 1993, Flammable liquid, n.o.s., Class 3, Packing Group III. ADR, IMDG, IATA and DOT requirements apply to packing, labelling and routing.

Hazards & Safe Handling

2,4-Dichlorofluorobenzene is a flammable liquid, harmful if swallowed, and irritating to skin and eyes. Standard precautions for a flammable halogenated aromatic liquid and good laboratory and plant practice apply throughout handling.

• Fire precautions. Keep away from heat, sparks, open flame and other ignition sources given its flash point of about 37 °C.
• Skin and eye contact. Chemical-resistant gloves and goggles are standard practice; rinse thoroughly with water on contact.
• Inhalation. Use adequate ventilation; avoid breathing vapour.
• PPE. Chemical-resistant gloves, safety goggles and, where ventilation is limited, a suitable respirator.

Regulatory & Compliance Notes

2,4-Dichlorofluorobenzene is a registered specialty halogenated aromatic shipped under Class 3 flammable-liquid rules. Because obligations differ by territory and use, the notes below are orientation rather than legal advice — confirm your own position with your regulatory adviser.

• GHS classification. Classified as a flammable liquid, harmful if swallowed, and irritating to skin and eyes (Signal word: Warning); the SDS carries the full hazard statements for your grade.
• REACH and chemical inventories. Registered under EU REACH and listed on major chemical inventories.
• Dangerous goods transport. UN 1993, Flammable liquid, n.o.s., Class 3, Packing Group III. ADR, IMDG, IATA and DOT requirements apply to packing, labelling and routing. (Note: some source data referencing this compound has shown an apparently contradictory secondary "Class 9" mention alongside the Class 3 entry — our reading is that Class 3/PG III is the correct primary classification consistent with the compound's flash point, and we recommend confirming this against your own current SDS before relying on it for shipping documentation.)
• HS code. Commonly declared under the halogenated-benzene derivatives heading; confirm the exact tariff line with your customs broker for your jurisdiction.
• Pharmaceutical quality agreements. Pharma-intended buyers commonly expect documented purity, isomer purity and change control. Tell us what your agreement requires.

We Supply 2,4-Dichlorofluorobenzene Worldwide

Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship 2,4-Dichlorofluorobenzene from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.

• Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
• Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
• Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
• Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.

Buying 2,4-Dichlorofluorobenzene from Chelora

We are an independent sourcing and supply partner. For this product that means settling the end-use (pharmaceutical or agrochemical), the purity and isomer-purity grade, the packing format, and the quantity you are buying.

• Documentation on every lot. Batch-specific COA with assay and isomer breakdown, plus the current SDS.
• Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
• Quantities. Trial quantities through to larger bulk shipments on contract supply.
• Inspection. Independent third-party inspection available at loading when the contract requires it.
• Related halogenated benzenes. Other fluorochlorobenzene isomers alongside this product from one supplier.

How ordering works

• Send the enquiry. End-use, purity, isomer-purity grade, quantity, destination port and the Incoterm you buy on.
• We quote. Price, lead time, packing format and a sample COA, normally within one working day.
• Qualify the supply. For first orders or pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
• Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
• Allocation and QC. Material allocated and released against a batch-specific COA, with an independent inspection where the contract calls for it.
• Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.

Related Fluorochlorobenzene & Chloroaromatic Intermediates