2,3,4-Trifluoronitrobenzene 2,3,4-TFNB · CAS 771-69-7
Chelora Chemicals is a supplier of 2,3,4-Trifluoronitrobenzene, a triple-fluorinated nitrobenzene used as a key building block for fluoroquinolone antibiotics and other pharmaceutical actives that need an adjacent 2,3,4-trifluoro substitution pattern combined with nitro-group reactivity. Every consignment leaves with a batch-specific COA and the current SDS.
Also known as: 2,3,4-TFNB, 1,2,3-Trifluoro-4-nitrobenzene
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Price, lead time and a sample COA for 2,3,4-Trifluoronitrobenzene, usually within one working day. We ship worldwide.
Request a Quote Email the DeskDocumentation
- Batch-specific COA (assay, isomer purity, water content)
- Safety Data Sheet (SDS)
- Dangerous-goods transport documents, confirmed to your SDS
- Third-party inspection on request
- Certificate of origin
What is 2,3,4-Trifluoronitrobenzene?
2,3,4-Trifluoronitrobenzene is a benzene ring carrying three adjacent fluorine atoms and a nitro group, formula C₆H₂F₃NO₂. It is supplied as a light yellow to orange liquid.
Its commercial importance comes from the fluoroquinolone antibiotic family (ciprofloxacin-, levofloxacin- and related-class actives), where the 2,3,4-trifluoro pattern is carried through to the finished drug's quinolone core. The nitro group provides a convenient handle for reduction to the corresponding trifluoroaniline, or for use directly in cyclisation chemistry building the quinolone ring system.
Commercially it is produced by nitrating 1,2,3-trifluorobenzene, or via Halex (halogen-exchange) chemistry starting from a chloronitrobenzene precursor and potassium fluoride, with the Halex route being the more common large-scale approach given fluorine's cost relative to feedstock fluorobenzenes.
Handling follows standard precautions for a nitroaromatic liquid — chemical-resistant gloves and eye protection, adequate ventilation, and storage away from incompatible materials.
Why 2,3,4-Trifluoronitrobenzene specifically
- A fluoroquinolone-defining substitution pattern. The adjacent 2,3,4-trifluoro arrangement is carried directly into the quinolone core of several fluoroquinolone antibiotic actives.
- Pharma intermediate. A key building block for antibacterial drug synthesis at commercial scale.
- Nitro-group versatility. Can be reduced to 2,3,4-trifluoroaniline or used directly in downstream cyclisation chemistry.
- Distinct from mono- and difluoro analogues. The triple-fluorine pattern gives electronic and steric properties that mono- or difluoronitrobenzenes do not reproduce.
How 2,3,4-Trifluoronitrobenzene is Manufactured
2,3,4-Trifluoronitrobenzene is produced either by direct nitration of 1,2,3-trifluorobenzene, or by Halex fluorination of a chloronitrobenzene precursor using potassium fluoride, with the choice of route depending on feedstock economics.
- Ring functionalisation. Nitration of 1,2,3-trifluorobenzene, or Halex fluorination of a trichloronitrobenzene precursor with potassium fluoride.
- Isomer separation. The target 2,3,4-isomer is separated from other co-product isomers, typically by distillation given this material is a liquid.
- Purification. The isolated fraction is purified by distillation to the target assay specification.
- Quality release and packing. Assay, isomer purity and water content are confirmed against specification before the batch is packed and released under nitrogen where required.
Typical Commercial Specification
Figures below are representative of commercial-grade 2,3,4-trifluoronitrobenzene. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.
| Parameter | Typical Value |
|---|---|
| Appearance | Light yellow to orange liquid |
| 2,3,4-Trifluoronitrobenzene content | 98% min by GC assay |
| Isomer purity | Other trifluoronitrobenzene isomers, trace levels to grade |
| Water content | To grade, typically 0.2% max |
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical formula | C₆H₂F₃NO₂ |
| Molecular weight | 177.08 g/mol |
| Appearance | Light yellow to orange liquid |
| Boiling point (reduced pressure) | About 92 °C at 20 mmHg |
| Atmospheric boiling point | Confirm against your current SDS* |
| Density | About 1.541 g/mL at 25 °C |
| Flash point | About 93 °C (200 °F) |
| Water solubility | Low |
| Incompatibilities | Strong bases, strong oxidisers, strong reducing agents |
Behaviour in the process
2,3,4-Trifluoronitrobenzene's reactivity pattern is what pharma intermediate producers are buying:
- Nitro reduction. The nitro group reduces readily to give 2,3,4-trifluoroaniline, feeding further fluoroquinolone-intermediate chemistry.
- Cyclisation chemistry. Used directly in some quinolone-ring-forming sequences without prior reduction.
- Thermal stability. Stable under normal storage conditions; standard nitroaromatic precautions apply.
2,3,4-Trifluoronitrobenzene and Related Fluoronitrobenzenes
Choosing between fluoronitrobenzene grades comes down to how many fluorines, and in what pattern, the target active pharmaceutical ingredient needs.
| Material | Substitution | When it is the right choice |
|---|---|---|
| 2,3,4-Trifluoronitrobenzene | 2,3,4-triF, 1-NO₂ | Fluoroquinolone antibiotics needing this exact trifluoro pattern |
| para-Fluoronitrobenzene | 4-F, 1-NO₂ | Routes needing a single, highly SNAr-reactive fluorine |
| 2,4-Difluoronitrobenzene | 2,4-diF, 1-NO₂ | Routes needing two fluorines rather than three |
| 2,3,4-Trifluoroaniline | 2,3,4-triF, 1-NH₂ | Where the reduced amine, rather than the nitro precursor, is needed directly |
Stated plainly: fluoroquinolone synthesis built around the 2,3,4-trifluoro quinolone core needs this specific isomer — mono- or difluoronitrobenzenes have a different substitution pattern and are not drop-in substitutes.
Industries We Supply 2,3,4-Trifluoronitrobenzene To
The same trifluoronitrobenzene feeds pharmaceutical API manufacturers and custom-synthesis houses. What changes is the downstream chemistry and the documentation each requires.
Where 2,3,4-Trifluoronitrobenzene is Used
In fluoroquinolone synthesis
2,3,4-Trifluoronitrobenzene's three fluorines occupy the exact positions carried through to the quinolone core of several marketed and investigational fluoroquinolone antibiotics. This is the core value proposition over partially fluorinated analogues — the pattern cannot be built up late-stage as efficiently as it can be installed at this early intermediate.
Need a specific purity or isomer grade?
Tell us the purity and isomer-purity grade you need, your downstream chemistry, the packing format you can receive and the annual quantity. We will come back with a price, a lead time and a sample COA.
Quality Control & Testing
Every lot is released against a batch-specific Certificate of Analysis, with isomer purity reported alongside the main assay because carryover of other fluoronitrobenzene isomers affects downstream pharma reaction selectivity.
- 2,3,4-Trifluoronitrobenzene content — by GC assay, the primary grade measure.
- Isomer purity — other trifluoronitrobenzene isomer carryover, reported because it affects downstream chemistry.
- Water content — measured because moisture can affect downstream reaction yield, especially in reduction steps.
Common Process Problems & Likely Causes
| Symptom | Likely cause | What to check |
|---|---|---|
| Off-target reaction product | Other trifluoronitrobenzene isomer carryover | Isomer purity figure on the COA |
| Poor reduction yield | Water content or trace impurities | Water content and assay on the COA |
| Low cyclisation yield | Isomer carryover affecting ring-closure geometry | Isomer breakdown on the COA |
Packaging, Storage & Shipping
- Standard packing. Drums or jerricans, typically 25 – 200 kg net, with larger bulk formats on contract supply.
- Moisture protection. Keep sealed and protected from moisture ingress during storage.
- Temperature control. Store in a cool, dry, well-ventilated area away from direct sun, heat and ignition sources.
- Material compatibility. Avoid contact with strong bases, strong oxidisers and strong reducing agents.
- Transport classification. Confirm the UN number and transport class against your own current SDS before shipping — published sources for this specific compound did not report a confirmed UN number at drafting time.
Hazards & Safe Handling
2,3,4-Trifluoronitrobenzene is a nitroaromatic liquid and should be handled with the standard precautions that apply to this class of compound. Refer to the current SDS for your grade for the complete hazard classification.
- Skin and eye contact. Chemical-resistant gloves and goggles are standard practice for nitroaromatic liquids; rinse thoroughly with water on contact.
- Inhalation. Use adequate ventilation when handling, given the material's volatility.
- PPE. Chemical-resistant gloves, safety goggles and, where vapour exposure is a concern, a suitable respirator.
- Fire. Keep away from ignition sources given the reported flash point; store accordingly.
Regulatory & Compliance Notes
2,3,4-Trifluoronitrobenzene is a registered pharma-intermediate fluoroaromatic. Because obligations differ by territory and use, and because confirmed UN transport data for this compound was not found in public sources at drafting time, the notes below are orientation rather than legal advice.
- GHS classification. Refer to your supplier's current SDS for the full classification applicable to your grade.
- REACH and chemical inventories. Registered under EU REACH and listed on major chemical inventories.
- Dangerous goods transport. Confirm the UN number, transport class and packing group with your logistics/EHS team against your current SDS before shipping.
- HS code. Commonly declared under the nitro-compound derivatives heading; confirm the exact tariff line with your customs broker for your jurisdiction.
We Supply 2,3,4-Trifluoronitrobenzene Worldwide
Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship 2,3,4-Trifluoronitrobenzene from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.
- Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
- Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
- Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
- Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.
Buying 2,3,4-Trifluoronitrobenzene from Chelora
We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the purity and isomer-purity grade your application needs, the packing format, and the quantity you are buying — and confirming transport classification with you before the first shipment.
- Documentation on every lot. Batch-specific COA with assay and isomer breakdown, plus the current SDS.
- Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
- Quantities. Trial quantities through to larger bulk shipments on contract supply.
- Inspection. Independent third-party inspection available at loading when the contract requires it.
- Related fluoroaromatics. 2,3,4-Trifluoroaniline, potassium fluoride (the Halex fluoride source) and other fluoronitrobenzenes alongside this product from one supplier.
How ordering works
- Send the enquiry. Purity, isomer-purity grade, quantity, destination port and the Incoterm you buy on.
- We quote. Price, lead time, packing format and a sample COA, normally within one working day.
- Qualify the supply. For first orders or pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
- Confirm transport classification. We work with you and your logistics team to confirm the UN number and transport class for your lane.
- Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
- Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.
2,3,4-Trifluoronitrobenzene — Common Questions
The questions our technical desk is asked most often about 2,3,4-Trifluoronitrobenzene. If yours isn't here, call or email and you will reach someone who knows the chemistry.
What is the CAS number of 2,3,4-Trifluoronitrobenzene?
The CAS number for 2,3,4-Trifluoronitrobenzene is 771-69-7. Its molecular formula is C₆H₂F₃NO₂ with a molecular weight of 177.08 g/mol.
What is 2,3,4-Trifluoronitrobenzene used for?
It is used as a key building block for fluoroquinolone antibiotic synthesis, where its adjacent 2,3,4-trifluoro pattern is carried into the finished quinolone core, as well as a research and screening compound.
Do you supply 2,3,4-Trifluoronitrobenzene worldwide?
Yes. Chelora Chemicals supplies and exports 2,3,4-Trifluoronitrobenzene worldwide — across Asia Pacific, Europe, the Middle East, Africa and the Americas, as well as throughout India. Every consignment carries the COA and SDS.
How is 2,3,4-Trifluoronitrobenzene manufactured?
By nitrating 1,2,3-trifluorobenzene, or by Halex fluorination of a chloronitrobenzene precursor using potassium fluoride, then separating and purifying the target isomer by distillation.
Is 2,3,4-Trifluoronitrobenzene hazardous?
It is a nitroaromatic liquid handled with standard precautions for this class of compound. Refer to the current SDS for your grade for the complete hazard classification.
What is the UN number and transport classification?
A reliably confirmed, compound-specific UN number was not found in public sources at drafting time. Confirm transport classification against your own current SDS before relying on it for shipping documentation.
What are the boiling point and density?
The commonly reported boiling point of about 92 °C is measured at reduced pressure (20 mmHg), not atmospheric pressure. Density is about 1.541 g/mL at 25 °C. Confirm against your own supplier's COA for batch-specific figures and atmospheric boiling point.
How does it differ from para-fluoronitrobenzene?
para-Fluoronitrobenzene carries a single fluorine; 2,3,4-trifluoronitrobenzene carries three fluorines in an adjacent pattern specifically used in fluoroquinolone antibiotic synthesis. They are not interchangeable.
How should 2,3,4-Trifluoronitrobenzene be stored?
In sealed containers, cool, dry and away from direct sun, heat, ignition sources and strong bases or oxidisers.
What purity grades do you offer?
Standard commercial grade is 98% minimum by GC assay, with isomer purity and water content reported on the COA.
What packing sizes and order quantities are available?
Drums or jerricans, typically 25–200 kg net, with larger bulk formats available on contract supply. Orders run from trial quantities up to repeat bulk loads.
Ready to source 2,3,4-Trifluoronitrobenzene?
Send us your purity requirement and annual volume. You will get a price, a realistic lead time and a sample COA from someone who understands what the material has to do in your process — delivered anywhere in the world.