2,6-Difluorobenzonitrile 2,6-DFBN · CAS 1897-52-5
Chelora Chemicals is a supplier of 2,6-Difluorobenzonitrile, a symmetrically difluorinated benzonitrile used as a building block in pharmaceutical and agrochemical synthesis, including routes to diflubenzuron-class insect growth regulators and various pharma actives that need the nitrile group's downstream versatility. Every consignment leaves with a batch-specific COA and the current SDS.
Also known as: 2,6-DFBN, 2,6-Difluorobenzene-1-carbonitrile
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Price, lead time and a sample COA for 2,6-Difluorobenzonitrile, usually within one working day. We ship worldwide.
Request a Quote Email the DeskDocumentation
- Batch-specific COA (assay, melting point, moisture)
- Safety Data Sheet (SDS)
- Dangerous-goods transport documents, confirmed to your SDS
- Third-party inspection on request
- Certificate of origin
What is 2,6-Difluorobenzonitrile?
2,6-Difluorobenzonitrile is a benzene ring carrying two symmetrically placed fluorine atoms flanking a nitrile group, formula C₇H₃F₂N. It is supplied as a white to off-white crystalline solid, melting in the range of 25 – 28 °C — close enough to room temperature that it can appear solid or partially melted depending on ambient conditions.
Its value as an intermediate comes from combining the nitrile's downstream versatility — hydrolysable to an amide or carboxylic acid, reducible to an amine, or usable directly in cyclisation chemistry — with the 2,6-difluoro pattern that activates the ring toward certain substitution reactions and is a structural requirement in several agrochemical and pharmaceutical targets.
Commercially it is produced from 2,6-difluorobenzamide or via other nitrile-forming routes starting from a 2,6-difluoro-substituted aromatic precursor.
Handling follows standard precautions for a fluorinated aromatic nitrile — chemical-resistant gloves and eye protection, adequate ventilation and dust control, and storage away from incompatible materials.
Why 2,6-Difluorobenzonitrile specifically
- A symmetric difluoro-nitrile building block. The 2,6-difluoro pattern flanking the nitrile is a structural feature in several insect-growth-regulator and pharma actives.
- Nitrile versatility. Can be hydrolysed, reduced, or used directly in cyclisation chemistry depending on the target molecule.
- Agrochemical building block. A key starting material for diflubenzuron-class benzoylurea insect growth regulators.
- Pharma intermediate. Used in selected pharmaceutical synthesis routes requiring the 2,6-difluorophenyl motif.
How 2,6-Difluorobenzonitrile is Manufactured
2,6-Difluorobenzonitrile is typically produced by dehydration of 2,6-difluorobenzamide, or by other standard nitrile-forming routes starting from a suitably substituted 2,6-difluoro aromatic precursor.
- Nitrile formation. Dehydration of 2,6-difluorobenzamide, or an equivalent route from a 2,6-difluoro-substituted precursor, forms the nitrile group.
- Purification. The crude product is purified by crystallisation or distillation to the target assay specification.
- Quality release and packing. Assay, melting point and moisture content are confirmed against specification before the batch is packed and released.
Typical Commercial Specification
Figures below are representative of commercial-grade 2,6-difluorobenzonitrile. Tell us your downstream route and the grade you need, and we will advise on the specification to order against.
| Parameter | Typical Value |
|---|---|
| Appearance | White to off-white crystalline solid |
| 2,6-Difluorobenzonitrile content | 98% min by GC assay |
| Melting point | 25 – 28 °C |
| Moisture content | To grade, typically 0.2% max |
Physical & Chemical Properties
| Property | Value |
|---|---|
| Chemical formula | C₇H₃F₂N |
| Molecular weight | 139.10 g/mol |
| Appearance | White to off-white crystalline solid |
| Melting point | 25 – 28 °C |
| Boiling point | About 197 – 198 °C |
| Density | About 1.246 g/mL at 25 °C |
| Flash point | About 80 °C (176 °F) |
| Water solubility | Low |
| Incompatibilities | Strong acids, strong bases, strong oxidisers |
Behaviour in the process
2,6-Difluorobenzonitrile's reactivity pattern is what pharma and agro intermediate producers are buying:
- Nitrile hydrolysis. Can be hydrolysed under acidic or basic conditions to give 2,6-difluorobenzamide or 2,6-difluorobenzoic acid, both useful intermediates in their own right.
- Nitrile reduction. Reducible to the corresponding benzylamine for amine-based synthesis routes.
- Thermal stability. Stable under normal storage conditions away from incompatible reagents.
2,6-Difluorobenzonitrile and Related Fluoroaromatics
Choosing between fluorinated benzonitrile derivatives and related building blocks comes down to which functional handle the target synthesis needs.
| Material | Functional group | When it is the right choice |
|---|---|---|
| 2,6-Difluorobenzonitrile | Nitrile | Routes needing the nitrile's versatility (hydrolysis, reduction, cyclisation) |
| 2,6-Difluoroaniline | Amine | Where the free amine, not the nitrile precursor, is needed directly |
| 2,3,4-Trifluoronitrobenzene | Nitro | Routes needing three fluorines and nitro-group reactivity instead |
| ortho-Fluoroaniline | Amine | Routes needing only a single fluorine on the aniline |
Stated plainly: a synthesis built around diflubenzuron-class insect growth regulators, or any route that needs the nitrile's reactivity specifically, needs this compound — the corresponding aniline or nitrobenzene analogues are not drop-in substitutes.
Industries We Supply 2,6-Difluorobenzonitrile To
The same difluorobenzonitrile feeds an agrochemical formulator and a pharmaceutical intermediate producer. What changes is the downstream chemistry and the documentation each requires.
Where 2,6-Difluorobenzonitrile is Used
In downstream functionalisation
2,6-Difluorobenzonitrile is carried through nitrile hydrolysis, reduction, or cyclisation chemistry to build the target agrochemical or pharma intermediate. The nitrile's reactivity, combined with the 2,6-difluoro pattern, gives a versatile entry point that the corresponding aniline or nitrobenzene analogues cannot replicate as efficiently.
Need a specific purity grade?
Tell us the purity grade you need, your downstream chemistry, the packing format you can receive and the annual quantity. We will come back with a price, a lead time and a sample COA.
Quality Control & Testing
Every lot is released against a batch-specific Certificate of Analysis, with moisture content reported alongside the main assay because residual moisture affects downstream hydrolysis and reduction chemistry.
- 2,6-Difluorobenzonitrile content — by GC assay, the primary grade measure.
- Melting point — a fast purity and identity check.
- Moisture content — measured because moisture can affect downstream reaction yield.
Common Process Problems & Likely Causes
| Symptom | Likely cause | What to check |
|---|---|---|
| Poor hydrolysis yield | Moisture or trace impurities | Moisture content and assay on the COA |
| Low reduction yield | Impurity carryover affecting catalyst performance | Assay and impurity profile on the COA |
| Material arrives partially melted | Normal behaviour — melting point near ambient temperature | Not a quality defect; re-solidify and proceed as normal |
Packaging, Storage & Shipping
- Standard packing. Fibre drums or HDPE bags, typically 25 – 200 kg net, with larger bulk formats on contract supply.
- Moisture protection. Keep sealed and protected from moisture ingress during storage.
- Temperature control. Store in a cool, dry, well-ventilated area; given the low melting point, some softening or fusing in hot climates is expected and does not indicate off-spec material.
- Material compatibility. Avoid contact with strong acids, strong bases and strong oxidisers.
- Transport classification. Confirm the UN number and transport class against your own current SDS before shipping — published sources for this specific compound did not report a confirmed UN number at drafting time.
Hazards & Safe Handling
2,6-Difluorobenzonitrile is a fluorinated aromatic nitrile and should be handled with the standard precautions that apply to this class of compound. Refer to the current SDS for your grade for the complete hazard classification.
- Skin and eye contact. Chemical-resistant gloves and goggles are standard practice; rinse thoroughly with water on contact.
- Inhalation. Use adequate ventilation and dust control when handling the crystalline solid.
- PPE. Chemical-resistant gloves, safety goggles and, where dust is generated, a suitable respirator.
- Fire. Keep away from ignition sources given the reported flash point; store accordingly.
Regulatory & Compliance Notes
2,6-Difluorobenzonitrile is a registered specialty fluoroaromatic nitrile. Because obligations differ by territory and use, and because confirmed UN transport data for this compound was not found in public sources at drafting time, the notes below are orientation rather than legal advice.
- GHS classification. Refer to your supplier's current SDS for the full classification applicable to your grade.
- REACH and chemical inventories. Registered under EU REACH and listed on major chemical inventories.
- Dangerous goods transport. Confirm the UN number, transport class and packing group with your logistics/EHS team against your current SDS before shipping.
- HS code. Commonly declared under the nitrile derivatives heading; confirm the exact tariff line with your customs broker for your jurisdiction.
We Supply 2,6-Difluorobenzonitrile Worldwide
Chelora Chemicals is a supplier and export partner, not a single-plant trader. We ship 2,6-Difluorobenzonitrile from India and from partner sources to customers across Asia, Europe, the Middle East, Africa, and North and South America, handling the export documentation and freight so the material arrives ready to use.
- Incoterms. EXW, FOB, CIF, CFR and DAP quoted to suit your purchasing terms and freight arrangements.
- Ports. Regular shipments through Nhava Sheva (JNPT) and Mundra, with other ports arranged as routing allows.
- Documentation. Commercial invoice, packing list, certificate of origin, COA and SDS issued as a complete set.
- Flexible volumes. From trial quantities up to repeat bulk shipments on a supply contract.
Buying 2,6-Difluorobenzonitrile from Chelora
We are an independent sourcing and supply partner. For this product that means settling three things at enquiry: the purity grade your application needs, the packing format, and the quantity you are buying — and confirming transport classification with you before the first shipment.
- Documentation on every lot. Batch-specific COA with assay and moisture data, plus the current SDS.
- Analysis before commitment. Representative analysis shared ahead of a commercial order so your lab can qualify the material.
- Quantities. Trial quantities through to larger bulk shipments on contract supply.
- Inspection. Independent third-party inspection available at loading when the contract requires it.
- Related fluoroaromatics. 2,6-Difluoroaniline and other fluorobenzene derivatives alongside this product from one supplier.
How ordering works
- Send the enquiry. Purity grade, quantity, destination port and the Incoterm you buy on.
- We quote. Price, lead time, packing format and a sample COA, normally within one working day.
- Qualify the supply. For first orders or agro-/pharma-grade applications, we share the analysis so your technical team can sign off before you commit.
- Confirm transport classification. We work with you and your logistics team to confirm the UN number and transport class for your lane.
- Confirm the order. Proforma invoice issued; payment terms agreed against the volume and the relationship.
- Ship and document. Packed, labelled and loaded with the full export document set, and tracked through to arrival.
2,6-Difluorobenzonitrile — Common Questions
The questions our technical desk is asked most often about 2,6-Difluorobenzonitrile. If yours isn't here, call or email and you will reach someone who knows the chemistry.
What is the CAS number of 2,6-Difluorobenzonitrile?
The CAS number for 2,6-Difluorobenzonitrile is 1897-52-5. Its molecular formula is C₇H₃F₂N with a molecular weight of 139.10 g/mol.
What is 2,6-Difluorobenzonitrile used for?
It is a key building block for diflubenzuron-class insect growth regulators, and is also used in pharmaceutical synthesis requiring the 2,6-difluorophenyl motif.
Do you supply 2,6-Difluorobenzonitrile worldwide?
Yes. Chelora Chemicals supplies and exports 2,6-Difluorobenzonitrile worldwide — across Asia Pacific, Europe, the Middle East, Africa and the Americas, as well as throughout India. Every consignment carries the COA and SDS.
How is 2,6-Difluorobenzonitrile manufactured?
Typically by dehydration of 2,6-difluorobenzamide, or by an equivalent nitrile-forming route from a 2,6-difluoro-substituted aromatic precursor, followed by purification by crystallisation or distillation.
Is 2,6-Difluorobenzonitrile hazardous?
It is a fluorinated aromatic nitrile handled with standard precautions for this class of compound. Refer to the current SDS for your grade for the complete hazard classification.
What is the UN number and transport classification?
A reliably confirmed, compound-specific UN number was not found in public sources at drafting time. Confirm transport classification against your own current SDS before relying on it for shipping documentation.
What are the melting point, boiling point and density?
Typical figures are a melting point of 25 – 28 °C, a boiling point around 197 – 198 °C, and a density around 1.246 g/mL at 25 °C. Confirm against your own supplier's COA for batch-specific figures.
Why does the material sometimes arrive partially melted?
Its melting point (25 – 28 °C) sits close to typical ambient and transit temperatures, so the material can appear fully solid, partially fused, or melted depending on conditions. This is normal and does not indicate off-spec material.
How should 2,6-Difluorobenzonitrile be stored?
In sealed containers, cool and dry, and away from strong acids, strong bases and strong oxidisers.
What purity grades do you offer?
Standard commercial grade is 98% minimum by GC assay, with melting point and moisture content reported on the COA.
What packing sizes and order quantities are available?
Fibre drums or HDPE bags, typically 25–200 kg net, with larger bulk formats available on contract supply. Orders run from trial quantities up to repeat bulk loads.
Ready to source 2,6-Difluorobenzonitrile?
Send us your purity requirement and annual volume. You will get a price, a realistic lead time and a sample COA from someone who understands what the material has to do in your process — delivered anywhere in the world.