Ortho Fluoro Aniline
A high-purity fluorinated aromatic amine supplied for pharmaceutical and agrochemical intermediates, benzoxazole and heterocyclic synthesis, and fine chemical manufacture.
What is Ortho Fluoro Aniline?
Ortho Fluoro Aniline — OFA, or 2-fluoroaniline — is a colourless to amber liquid carrying a fluorine atom on the carbon next to the amino group.
Placing fluorine ortho rather than para changes the molecule's behaviour meaningfully. The amine becomes less basic, and the fluorine sits close enough to participate when the nitrogen is used to close a ring, which is why the ortho isomer is favoured in benzoxazole, benzimidazole, and quinoline synthesis.
At Chelora Chemicals, OFA is distilled to low colour and controlled isomer content, with moisture held tight, so that acylation, cyclisation, and coupling steps downstream run reproducibly at pharmaceutical intermediate quality.
- Appearance
- Colourless to amber liquid
- Odour
- Characteristic amine odour
- Solubility
- Slightly soluble in water; soluble in organic solvents
- Function
- Chemical intermediate
- Grade
- Technical / pharma intermediate
Formula diagram
Aniline ring with fluorine in the ortho position
- Molecular formulaC6H6FN
- Molecular weight111.12 g/mol
- IUPAC name2-Fluoroaniline
- Functional groupsPrimary aromatic amine, aryl fluoride
- CAS number348-54-9
Technical product information
Standard specification for Chelora Chemicals' technical and pharma-intermediate grade Ortho Fluoro Aniline. Custom-grade and bulk specifications are available on request.
| Chemical name | Ortho Fluoro Aniline |
|---|---|
| Synonyms | OFA, 2-Fluoroaniline, o-Fluoroaniline, 2-Aminofluorobenzene |
| CAS number | 348-54-9 |
| Molecular formula | C6H6FN |
| Molecular weight | 111.12 g/mol |
| Assay (GC purity) | ≥ 99.5% |
| Appearance | Clear, colourless to amber liquid |
| Density (20°C) | 1.150–1.162 g/cm³ |
| Boiling point | 174–176°C |
| Flash point | ≈ 66°C (closed cup) |
| Refractive index (20°C) | 1.538–1.545 |
| Water content | ≤ 0.2% |
| Packaging | 200 kg drums, 1000 kg IBC |
| Shelf life | 12 months in sealed original packaging |
Applications of Ortho Fluoro Aniline
Pharmaceutical intermediates
A building block in fluorinated API synthesis, particularly where the ring is later closed into a heterocycle.
Heterocyclic synthesis
Condensed into benzoxazoles, benzimidazoles, and quinolines requiring an ortho-substituted aniline.
Agrochemicals
Introduces a fluorinated aniline fragment into insecticide and herbicide actives.
Dyes & pigments
Diazotised to give fluorinated colour components with distinctive shade and fastness.
Liquid crystal materials
Feeds fluorinated intermediates used in display material manufacture.
Fine chemicals
Supplied as a research and custom-synthesis building block.
Why choose Chelora Chemicals
Every batch of Ortho Fluoro Aniline is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
GC assay controlled at ≥99.5% with colour, isomer profile, and water content verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 200 kg drums to IBC quantities, with laboratory samples on request.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly sealed original containers under nitrogen where possible.
- 02Keep in a cool, dry, well-ventilated store away from heat and direct sunlight.
- 03Protect from air and light — the product darkens on oxidation.
- 04Segregate from strong oxidising agents, acids, and acid chlorides.
- 05Use compatible containers: glass, lined steel, stainless steel, or HDPE.
- 06Re-seal drums promptly after use and maintain nitrogen blanketing on bulk storage.
Handling precautions
OFA is a toxic aromatic amine, harmful in contact with skin, by inhalation, and if swallowed. It is for industrial use by trained personnel only.
Aromatic amines are readily absorbed through intact skin and can affect the blood by forming methaemoglobin. Chemical-resistant gloves, coveralls, and eye protection are required.
The product is combustible above its flash point of about 66°C. Keep away from ignition sources and earth equipment during transfer.
Use local exhaust ventilation for drum decanting, charging, and heated operations; avoid breathing vapour or mist.
Refer to the full Safety Data Sheet for exposure limits, spill containment, disposal, and first-aid measures before use.
Frequently asked questions
What is Ortho Fluoro Aniline used for?
It is an intermediate for fluorinated pharmaceuticals and agrochemicals, and particularly for heterocycle formation where the ortho position needs to be available for ring closure.
How does OFA differ from PFA?
Both are C6H6FN with a weight of 111.12, differing only in whether the fluorine sits ortho or para to the amino group. The ortho isomer is less basic and is chosen for cyclisation chemistry; the para isomer is the more general-purpose building block.
Why is the ortho position significant?
Reactions that close a ring onto the aniline need the position next to the nitrogen to be involved. With fluorine there, that position is both blocked to unwanted substitution and available as a leaving group under activation, which shapes what heterocycles can be made.
Is the fluorine reactive?
Not under ordinary conditions. On a ring without strong activating groups, the carbon–fluorine bond is very stable, so the amine is the reactive handle in most syntheses.
Why does the liquid turn amber or brown?
Aromatic amines oxidise slowly on contact with air and light. Assay is usually unaffected, but sealed, cool, dark, nitrogen-blanketed storage preserves colour for pharmaceutical intermediate use.
Is it soluble in water?
Only slightly. It is readily soluble in alcohols, ethers, esters, and aromatic hydrocarbons, so reactions are normally run in organic media.
What purity do you supply?
Standard grade is supplied at a minimum GC assay of 99.5% with water content at or below 0.2%. Higher assay and low-colour specifications for pharmaceutical intermediate use can be manufactured to order.
What packaging sizes are available?
200 kg drums and 1000 kg IBCs, with laboratory and pilot samples available for development work.
How long can it be stored?
12 months from manufacture in sealed original packaging under the recommended conditions. Nitrogen blanketing and cool, dark storage materially extend colour stability.
Is OFA hazardous?
Yes. It is toxic, skin-absorbable, combustible above about 66°C, and hazardous to aquatic life. Engineering controls, PPE, and the Safety Data Sheet should be reviewed before handling.
Do you provide a Certificate of Analysis?
Yes. Each batch ships with a Certificate of Analysis and Safety Data Sheet covering GC assay, colour, refractive index, density, water content, and appearance.