2-Hydrazino-4-methylbenzothiazole
A high-purity substituted benzothiazole hydrazine supplied for heterocyclic construction, pharmaceutical and agrochemical intermediates, and analytical derivatisation.
What is 2-Hydrazino-4-methylbenzothiazole?
2-Hydrazino-4-methylbenzothiazole — HMBT, also catalogued as 4-methyl-2-benzothiazolehydrazine — is an off-white to pale yellow crystalline solid built on a fused benzothiazole core with a hydrazine group at the 2-position.
The hydrazine is the working end of the molecule. It condenses readily with aldehydes and ketones to give hydrazones, and it can be cyclised with a range of one-carbon and two-carbon partners into triazoles, thiadiazoles, and other fused ring systems — which is why it appears so often in medicinal and agrochemical scaffold building.
At Chelora Chemicals, HMBT is crystallised and refined with assay, melting range, and moisture held to specification, and handled to limit the oxidation to which aryl hydrazines are prone.
- Appearance
- Off-white to pale yellow crystalline powder
- Odour
- Faint amine-like
- Solubility
- Slightly soluble in water; soluble in alcohols and DMF
- Function
- Chemical intermediate
- Grade
- High purity
Formula diagram
A benzothiazole core carrying a hydrazine group at C-2
- Molecular formulaC8H9N3S
- Molecular weight179.24 g/mol
- IUPAC name2-Hydrazinyl-4-methyl-1,3-benzothiazole
- Functional groupsHydrazine, benzothiazole
- CAS number20174-68-9
Technical product information
Standard specification for Chelora Chemicals' high-purity intermediate 2-Hydrazino-4-methylbenzothiazole. Custom-grade and bulk specifications are available on request.
| Chemical name | 2-Hydrazino-4-methylbenzothiazole |
|---|---|
| Synonyms | HMBT, 4-Methyl-2-benzothiazolehydrazine, 2-Hydrazinyl-4-methylbenzothiazole |
| CAS number | 20174-68-9 |
| Molecular formula | C8H9N3S |
| Molecular weight | 179.24 g/mol |
| Assay (HPLC purity) | ≥ 98.0% |
| Appearance | Off-white to pale yellow crystalline powder |
| Melting point | 195–205°C (with decomposition) |
| Loss on drying | ≤ 0.5% |
| Residue on ignition | ≤ 0.2% |
| Packaging | 1 kg, 5 kg & 25 kg drums |
| Storage | Cool, dry, protected from light and air |
| Shelf life | 12 months in sealed original packaging |
Applications of 2-Hydrazino-4-methylbenzothiazole
Heterocyclic synthesis
Cyclised into triazolo- and thiadiazolo-fused ring systems used across medicinal chemistry.
Hydrazone formation
Condenses with aldehydes and ketones to give stable, often crystalline hydrazone derivatives.
Pharmaceutical intermediates
Provides a benzothiazole scaffold for API and development compound synthesis.
Agrochemical intermediates
Used in crop-protection routes built on benzothiazole and triazole chemistry.
Analytical derivatisation
Applied as a derivatising reagent for carbonyl compounds in analytical chemistry.
Custom synthesis
Supplied as a research and contract manufacturing building block.
Why choose Chelora Chemicals
Every batch of 2-Hydrazino-4-methylbenzothiazole is manufactured, tested, and documented to a standard that formulators and process chemists can build on with confidence — from first sample to full production volume.
Consistent purity
HPLC assay controlled at ≥98% with melting range and loss on drying verified before dispatch.
Full documentation
COA, SDS, and regulatory data supplied with every shipment.
Flexible volumes
From 1 kg laboratory packs to 25 kg drums.
Technical support
Process, handling, and compliance guidance from our chemistry team.
Storage and guidelines
- 01Store in tightly closed original packaging under nitrogen where possible.
- 02Keep cool, dry, and protected from light; refrigerated storage extends stability.
- 03Protect from air — aryl hydrazines oxidise and darken on prolonged exposure.
- 04Segregate from strong oxidising agents, acids, and nitrous acid sources.
- 05Control dust during drum emptying and charging, and re-seal packaging promptly.
- 06Prevent release to drains, surface water, and soil.
Handling precautions
HMBT is harmful if swallowed or inhaled, causes skin and eye irritation, and may cause an allergic skin reaction. It is for industrial use by trained personnel only.
Hydrazine derivatives as a class warrant particular caution: many are sensitisers and several are suspected of genotoxic or carcinogenic effects. Treat exposure prevention as the primary control rather than relying on exposure limits.
Contact with strong oxidising agents or nitrous acid can be vigorous and must be avoided. Segregate these materials physically.
Use chemical-resistant gloves, coveralls, eye protection, and dust control at every transfer point.
The product melts with decomposition, so avoid heating above the melting range during drying or processing.
Refer to the full Safety Data Sheet for exposure limits, health surveillance, spill response, and first-aid measures before use.
Frequently asked questions
What is 2-Hydrazino-4-methylbenzothiazole used for?
It is a building block for fused heterocycles, particularly triazolo- and thiadiazolo-benzothiazoles, used in pharmaceutical and agrochemical discovery and manufacture. It also serves as a derivatising reagent for carbonyl compounds.
Is HMBT the same as 4-methyl-2-benzothiazolehydrazine?
Yes. Both names describe CAS 20174-68-9 and appear in catalogues interchangeably. If you see them listed as separate products, they are duplicates of the same material.
What does the hydrazine group do?
It provides two adjacent nitrogens that can condense with a carbonyl to form a hydrazone, or react with a second partner and cyclise into a five-membered nitrogen ring fused to the existing scaffold.
Why is the benzothiazole core useful in drug discovery?
It is a rigid, planar, sulfur-containing scaffold that appears in many biologically active molecules. Combining it with a hydrazine handle gives medicinal chemists a direct route into fused ring systems from a single starting material.
Why does the product darken during storage?
Aryl hydrazines oxidise on contact with air and light. Assay is usually unaffected by moderate colour development, but nitrogen blanketing and cool, dark storage slow it considerably.
Is it soluble in water?
Only slightly. It dissolves in ethanol, methanol, DMF, and DMSO, which are the usual media for condensation and cyclisation chemistry.
Why does the melting point come with a decomposition note?
The compound decomposes as it melts rather than melting cleanly, which is common for hydrazine derivatives. This means drying and processing should stay well below the melting range.
What safety concerns are specific to hydrazines?
Many hydrazine derivatives are sensitisers and several are suspected of genotoxic or carcinogenic effects, so exposure prevention is the priority. They also react vigorously with oxidising agents and nitrous acid, which must be segregated.
What purity do you supply?
Standard grade is supplied at a minimum HPLC assay of 98% with loss on drying at or below 0.5%. Tighter specifications can be manufactured to order.
What packaging sizes are available?
1 kg and 5 kg laboratory packs and 25 kg drums, with samples available for development work.
How long can it be stored?
12 months in sealed original packaging kept cool, dry, dark, and preferably under nitrogen. Older material should be re-assayed before use in a regulated route.
Do you provide a Certificate of Analysis?
Yes. Every batch is dispatched with a Certificate of Analysis and Safety Data Sheet covering HPLC assay, melting range, loss on drying, and appearance.